For any professional involved in chemical procurement or synthesis, a thorough understanding of a compound's chemical profile is indispensable. 3-(3-Methoxyphenyl)propionic acid (CAS: 10516-71-9) is a compound that warrants close examination due to its significant role as a pharmaceutical intermediate and in various organic synthesis applications. This article delves into its key chemical properties, typical synthesis routes, and the critical importance of purity when sourcing this material.

Understanding the Chemical Identity and Properties

3-(3-Methoxyphenyl)propionic acid, with the molecular formula C10H12O3 and a molecular weight of 180.2 g/mol, is characterized by its aromatic ring bearing a methoxy group and a propionic acid side chain. Available typically as a white to light yellow crystalline solid, its melting point is generally reported in the range of 43-45 °C. Its solubility in common solvents like DMSO and water (as indicated in some sources) is an important consideration for reaction setup and formulation. The presence of the carboxylic acid group makes it acidic, with a pKa of approximately 4.654 at 25°C.

Synthesis Pathways for Reliable Production

The synthesis of 3-(3-Methoxyphenyl)propionic acid often involves the catalytic hydrogenation of its unsaturated precursor, such as 3-(3-methoxyphenyl)cinnamic acid, using a palladium on charcoal catalyst. This method, when carried out under controlled conditions, yields the desired saturated acid with high efficiency and purity. For manufacturers, optimizing these synthesis routes is key to ensuring consistent production and managing costs, making it a more accessible chemical for buyers.

The Crucial Role of Purity in Applications

When you buy 3-(3-Methoxyphenyl)propionic acid, especially for pharmaceutical applications, purity is non-negotiable. High purity levels, often exceeding 97% or 98% as indicated by GC or HPLC analysis, are critical. Impurities can lead to side reactions, reduce the efficacy of the final product, and even pose safety risks in pharmaceutical formulations. Therefore, it is vital to source this compound from reputable manufacturers and suppliers who rigorously test their products and provide comprehensive Certificates of Analysis (CoA). Understanding the purity specifications and how they are verified will give you confidence in the material's suitability for your specific requirements.

Sourcing and Procurement Considerations

As a sought-after intermediate, 3-(3-Methoxyphenyl)propionic acid is available from numerous suppliers globally, with many prominent manufacturers located in China. When comparing prices and availability, consider the supplier's commitment to quality control, their production capacity, and their logistical capabilities. Requesting samples is a standard practice to verify quality before placing larger orders. For industrial-scale needs, securing a long-term supply agreement with a trusted manufacturer can ensure continuity and predictable pricing.

In conclusion, a deep understanding of the chemical properties, synthesis, and purity standards of 3-(3-Methoxyphenyl)propionic acid empowers researchers and manufacturers to make informed procurement decisions, ultimately contributing to the success of their complex chemical projects.