In the intricate landscape of chemical synthesis, understanding the precise nature of chemical intermediates is fundamental to successful research and development. 3-Phenoxypropyl bromide, identified by CAS number 588-63-6, stands out as a key intermediate, particularly valued for its specific chemical profile and reactivity. For any professional looking to buy 3-Phenoxypropyl bromide, a deep dive into its characteristics is essential.

The compound's systematic name, 3-Phenoxypropyl bromide, clearly indicates its structure: a three-carbon alkyl chain connecting a phenoxy group (a phenyl ring attached via an oxygen atom) to a terminal bromine atom. This structure endows it with distinct chemical properties. Its molecular formula is C9H11BrO, with a molecular weight of approximately 215.09 g/mol. The presence of the aromatic phenyl ring contributes hydrophobic characteristics, while the ether linkage and the polarizable carbon-bromine bond influence its reactivity and solubility.

The primary reactive center in 3-Phenoxypropyl bromide is the carbon atom bonded to the bromine. Bromine is an excellent leaving group, making this position highly susceptible to nucleophilic attack. This property enables 3-Phenoxypropyl bromide to participate readily in SN2 reactions. For example, reacting it with amines can form substituted amines, with alcohols can form new ethers, and with thiolates can form thioethers. These transformations are foundational in building more complex organic molecules, especially in the pharmaceutical sector.

Beyond direct substitution, the carbon-bromine bond can also be converted into an organometallic reagent, such as a Grignard reagent (by reacting with magnesium) or an organolithium species (by reacting with lithium). These highly reactive organometallic compounds are powerful tools for forming new carbon-carbon bonds, significantly expanding the synthetic utility of 3-Phenoxypropyl bromide in creating intricate carbon skeletons.

The phenoxy ether portion of the molecule also contributes to its profile. While generally stable, the ether linkage can be cleaved under harsh acidic conditions (e.g., using strong Lewis acids or concentrated hydrohalic acids), which might offer alternative synthetic routes or need to be considered for reaction compatibility. The aromatic ring itself can also undergo electrophilic aromatic substitution, though this typically requires specific activating conditions and is less common than reactions involving the bromide.

The significance of 3-Phenoxypropyl bromide as an intermediate is particularly evident in pharmaceutical synthesis. Its structure is often incorporated into drug molecules, and the reactive bromide allows for precise attachment of other molecular fragments. Therefore, sourcing high-purity material, typically 99.0% or higher, from a reliable manufacturer or supplier of 3-Phenoxypropyl bromide is paramount for consistent and successful outcomes in drug development and other fine chemical applications.

In essence, the chemical profile of 3-Phenoxypropyl bromide—defined by its reactive bromide and stable phenoxy ether—makes it a highly valuable intermediate. Its ability to undergo various well-understood organic reactions makes it indispensable for chemists aiming to synthesize complex target molecules efficiently and effectively.