In the intricate world of pharmaceutical manufacturing, understanding the precise chemical and physical properties of intermediates is crucial for successful synthesis and product development. 4-(4-Bromo-3-formylphenoxy)benzonitrile, identified by its CAS number 906673-54-9, is a prime example of such a vital compound. It serves as a key intermediate in the production of Crisaborole, a significant therapeutic agent for dermatological conditions. This article delves into the chemical profile of this compound, highlighting the properties that make it indispensable for pharmaceutical applications.

Chemical Identity and Structure

4-(4-Bromo-3-formylphenoxy)benzonitrile possesses the molecular formula C14H8BrNO2 and a molecular weight of approximately 302.12 g/mol. Its structure is characterized by a central benzonitrile ring linked via an ether bond to a phenyl ring that is substituted with a bromine atom and a formyl (aldehyde) group. These functional groups are strategically positioned to facilitate specific chemical transformations required in the synthesis of Crisaborole.

Key Physical and Chemical Properties

Manufacturers and researchers often rely on a set of standardized properties to ensure the consistent quality and suitability of this intermediate:

  • Appearance: Typically described as a white to light yellow solid, often in powder form. This visual characteristic is a primary indicator of its physical state and initial quality assessment.
  • Purity: High purity is paramount for pharmaceutical intermediates. Reputable suppliers, including manufacturers in China, commonly offer this compound with a purity of ≥98.0%, often exceeding 99%. Low levels of single impurities and total impurities are rigorously controlled.
  • Melting Point: The reported melting point range, often around 109-111°C, provides a critical parameter for identifying and assessing the purity of the compound.
  • Solubility: Information on solubility in common solvents, such as DMSO and methanol, is important for developing effective reaction and purification protocols.
  • Storage Conditions: Proper storage, typically under inert gas at refrigerated temperatures (e.g., 2-8°C), is recommended to maintain its stability and chemical integrity over time.

NINGBO INNO PHARMCHEM CO.,LTD. is a dedicated supplier of high-quality pharmaceutical intermediates like 4-(4-Bromo-3-formylphenoxy)benzonitrile. We provide comprehensive product specifications and technical data to support your R&D and manufacturing needs. If you are looking to buy this essential intermediate, we encourage you to contact us for a quote and detailed product information. As a reliable manufacturer, we ensure adherence to stringent quality standards for all our products.

Understanding the detailed chemical profile of intermediates is fundamental to successful pharmaceutical development. By focusing on compounds with well-defined properties and partnering with expert manufacturers, the industry can continue to bring life-changing treatments to patients.