4-Bromo-2,6-dimethylaniline (CAS 24596-19-8) is a chemical compound that plays a significant role in various industrial applications, most notably as a key intermediate in pharmaceutical synthesis. For R&D scientists and product formulators, a thorough understanding of its physical and chemical properties is essential for effective utilization. This article provides a detailed overview of this compound's characteristics and its diverse applications, highlighting why it's a sought-after material from reliable chemical suppliers.

Understanding the Chemical Identity

Known by its CAS number 24596-19-8, 4-Bromo-2,6-dimethylaniline is also recognized by several other names, including 4-amino-3,5-dimethylbromobenzene, 4-Bromo-2,6-dimethyl-phenylamine, and 2-Amino-5-bromo-m-xylene. This array of nomenclature underscores its versatility and presence in different chemical contexts.

Key Physical and Chemical Properties

The utility of any chemical intermediate is dictated by its inherent properties. For 4-Bromo-2,6-dimethylaniline, these include:

  • Appearance: It typically presents as a brown crystal. This visual cue is important for initial identification and quality assessment.
  • Density: With a density of 1.4±0.1 g/cm³, it indicates a relatively dense organic molecule.
  • Boiling Point: The compound has a boiling point of 258.8±35.0 °C at 760 mmHg, suggesting reasonable thermal stability for certain processing conditions.
  • Melting Point: A melting point range of 48-51 °C indicates that it exists as a solid at ambient temperatures but can be melted for processing or purification.
  • Molecular Formula and Weight: Its molecular formula is C₈H₁₀BrN, with a molecular weight of 200.076. This information is critical for stoichiometric calculations in synthesis.
  • Flash Point: A flash point of 110.3±25.9 °C provides insights into its flammability and necessary handling precautions.
  • Assay: Typically supplied with an assay of ≥98.0%, ensuring a high degree of purity essential for its intended applications.

Primary Applications and Industrial Relevance

The most significant application of 4-Bromo-2,6-dimethylaniline is as a crucial intermediate in the synthesis of Rilpivirine (CAS: 500287-72-9). Rilpivirine is a non-nucleoside reverse transcriptase inhibitor used in the treatment of HIV-1 infection. The precise structure and purity of 4-Bromo-2,6-dimethylaniline directly impact the yield and quality of the final pharmaceutical product.

Beyond its pharmaceutical role, its brominated aromatic structure makes it a valuable building block for other fine chemicals, potentially finding use in the development of dyes and agrochemical intermediates. For companies looking to purchase 4-Bromo-2,6-dimethylaniline, understanding these properties allows for informed decisions regarding process design and application suitability.

Sourcing and Availability

For procurement managers seeking this compound, identifying a reliable 4-Bromo-2,6-dimethylaniline supplier in China is key. Manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. offer this intermediate with guaranteed high purity and can provide detailed technical specifications. Engaging with such a manufacturer ensures access to a consistently high-quality product for your synthesis needs.

By understanding the detailed chemical profile of 4-Bromo-2,6-dimethylaniline, researchers and procurement specialists can confidently select and utilize this essential intermediate, ensuring the success of their synthesis projects and ultimately, the quality of their end products.