For research and development professionals in the chemical and pharmaceutical industries, a thorough understanding of the building blocks they use is fundamental. 4-Bromo-4'-methylbiphenyl, identified by its CAS number 50670-49-0, is a compound of particular interest due to its versatile chemical profile and utility in complex synthesis. This article delves into its properties, reactivity, and applications, offering valuable insights for scientists and researchers.

Chemically, 4-Bromo-4'-methylbiphenyl possesses the molecular formula C₁₃H₁₁Br, with a molecular weight of approximately 247.13 g/mol. It typically presents as a white to yellow or orange crystalline powder. Key physical properties, such as a melting point often cited in the range of 131-135°C, are important considerations for laboratory handling and reaction condition optimization. Its limited solubility in water is also a typical characteristic of such aromatic organic compounds.

The reactivity of 4-Bromo-4'-methylbiphenyl is primarily governed by its biphenyl structure and the functional groups attached. The bromine atom on one phenyl ring is strategically positioned to participate in a wide array of synthetic transformations. Most notably, it is highly amenable to palladium-catalyzed cross-coupling reactions. These include Suzuki-Miyaura coupling (with boronic acids/esters), Heck coupling (with alkenes), and Buchwald-Hartwig amination (with amines), among others. These reactions are cornerstones of modern synthetic organic chemistry, enabling the formation of intricate molecular architectures and new carbon-carbon or carbon-heteroatom bonds. The methyl group on the other phenyl ring can also influence reactivity, potentially directing electrophilic aromatic substitution or offering a site for further functionalization.

The applications of 4-Bromo-4'-methylbiphenyl are diverse and driven by its synthetic versatility. It serves as a critical intermediate in the preparation of pharmaceutical compounds, where its structure can be elaborated into active pharmaceutical ingredients (APIs) or their precursors. In material science, it is employed as a building block for synthesizing advanced functional materials, such as liquid crystals, organic semiconductors, and components for OLED displays, due to its conjugated aromatic system. Researchers also find it useful in academic studies exploring new synthetic methodologies or investigating the effects of halogen bonding.

For R&D professionals seeking to procure 4-Bromo-4'-methylbiphenyl, it is essential to partner with reliable suppliers who can guarantee purity and consistency. Understanding the specific needs of your synthesis, whether it's for early-stage research or pilot-scale production, will inform your purchasing decisions. Engaging with manufacturers who can provide detailed analytical data and technical support ensures that you receive material fit for purpose, ultimately contributing to the success of your research endeavors.