For professionals in chemistry-driven industries, a thorough understanding of chemical intermediates is fundamental to successful synthesis and product development. 4-Chlorobutyryl Chloride (CAS 4635-59-0), a prominent acyl chloride, demands attention due to its unique chemical profile and broad applicability.

This compound, identified by its CAS number 4635-59-0 and molecular formula C4H6Cl2O, presents as a clear, colorless to yellow liquid. Its physical properties, such as a melting point of approximately -47°C and a boiling point around 173-174°C, indicate its liquid state under standard conditions. A key characteristic is its sensitivity to moisture; it hydrolyzes in the presence of water, necessitating careful handling and storage under dry, inert conditions. This hygroscopic nature is typical for acyl chlorides and underscores the importance of proper packaging and storage protocols, such as keeping it in tightly sealed containers under nitrogen.

The reactivity of 4-Chlorobutyryl Chloride stems from its two functional groups. The acyl chloride moiety is highly electrophilic, making it an excellent reagent for acylation reactions – the introduction of an acyl group into organic molecules. This can occur via esterification with alcohols, amidation with amines, or Friedel-Crafts acylation with aromatic compounds. Concurrently, the terminal chlorine atom provides another site for nucleophilic substitution reactions, allowing for further functionalization or the creation of carbon-carbon bonds.

This dual reactivity profile makes 4-Chlorobutyryl Chloride indispensable in synthesizing complex organic molecules. It serves as a vital intermediate in the production of various pharmaceuticals, agrochemicals, and specialty polymers. For instance, its role in the synthesis of Fexofenadine highlights its importance in the pharmaceutical industry. The ability to accurately source this chemical is paramount for R&D scientists and procurement managers. When looking to buy 4-Chlorobutyryl Chloride, emphasis should be placed on obtaining detailed technical specifications, including purity levels (often >99%) and any specific impurity profiles.

Establishing a relationship with a reliable manufacturer or supplier, particularly from regions with strong chemical manufacturing infrastructure like China, can ensure access to high-quality material at competitive prices. Thorough vetting of suppliers, including requesting samples for analysis and verifying their quality management systems, is a critical step in the procurement process. Understanding the Material Safety Data Sheet (MSDS) for 4-Chlorobutyryl Chloride is also essential for safe handling, storage, and disposal, given its corrosive and moisture-sensitive nature.

In conclusion, 4-Chlorobutyryl Chloride is a chemically significant intermediate whose properties enable diverse synthetic applications. By understanding its chemical profile and adhering to best practices for sourcing and handling, businesses can effectively leverage this compound for their critical manufacturing needs.