Understanding the chemical properties of key intermediates is fundamental to their effective use in synthesis. 4-Fluoro-2-Methoxy-5-Nitroaniline, a vital organic compound, possesses a distinct chemical profile that makes it indispensable in the pharmaceutical industry. NINGBO INNO PHARMCHEM CO.,LTD. provides a detailed overview of this compound's characteristics and its primary application in the creation of advanced anticancer agents.

Chemically, 4-Fluoro-2-Methoxy-5-Nitroaniline is an aromatic amine derivative with the molecular formula C7H7FN2O3 and a molecular weight of approximately 186.14 g/mol. Physically, it typically presents as a yellow solid. This specific structure, featuring a fluorine atom at the 4-position, a methoxy group at the 2-position, and a nitro group at the 5-position of an aniline ring, dictates its reactivity and suitability for particular synthetic routes. Its solubility characteristics, generally soluble in organic solvents and sparingly soluble in water, are also important considerations for reaction design and purification processes.

The most prominent application of 4-Fluoro-2-Methoxy-5-Nitroaniline is its role as a key intermediate in the synthesis of Mereletinib. Mereletinib is a targeted therapy that inhibits the activity of mutated epidermal growth factor receptors (EGFR), which are implicated in the growth and proliferation of certain types of cancer, particularly non-small cell lung cancer. The synthesis pathway involves several steps where 4-Fluoro-2-Methoxy-5-Nitroaniline is strategically transformed to build the complex molecular architecture of Mereletinib. The precise arrangement of functional groups on this intermediate is crucial for its successful incorporation into the final drug molecule.

Beyond its critical role in Mereletinib synthesis, the unique combination of electron-donating (methoxy) and electron-withdrawing (nitro) groups, alongside the electronegative fluorine atom, makes 4-Fluoro-2-Methoxy-5-Nitroaniline a versatile compound for various other organic synthesis applications. Medicinal chemists can leverage its reactivity to explore new therapeutic targets and design novel drug candidates. The reliable purchase of 4-Fluoro-2-Methoxy-5-Nitroaniline from reputable suppliers like NINGBO INNO PHARMCHEM CO.,LTD. ensures that these research endeavors have access to high-quality materials.

NINGBO INNO PHARMCHEM CO.,LTD. is committed to supplying chemical intermediates that meet exacting standards. Our understanding of the chemical profile of 4-Fluoro-2-Methoxy-5-Nitroaniline allows us to support the vital work of the pharmaceutical industry in developing more effective treatments for diseases.