Understanding the detailed chemical and physical profile of a compound is fundamental for its effective application in synthesis and product development. 4'-tert-Butyl-4-chlorobutyrophenone, identified by CAS number 43076-61-5, is a key intermediate whose characteristics make it valuable in various chemical processes. This article explores its core properties and highlights its significance as a versatile building block in the fine chemical and pharmaceutical industries.

At its most basic description, 4'-tert-Butyl-4-chlorobutyrophenone presents as a white to very slightly yellow powder. This physical appearance is often the first indicator of its purity and form. Its molecular formula is C14H19ClO, which precisely defines the elemental composition and atomic arrangement. The molecular weight is calculated to be 238.75 g/mol. This relatively moderate molecular weight makes it amenable to a wide range of synthetic manipulations.

The structure itself is a butyrophenone derivative, featuring a phenyl ring substituted with a tert-butyl group at the para position, and a four-carbon chain attached to the carbonyl group, with a chlorine atom at the terminal end of the chain. This specific arrangement is crucial for its reactivity. The presence of the chlorine atom on the alkyl chain offers a reactive leaving group, enabling nucleophilic substitution reactions. Concurrently, the ketone functionality can undergo nucleophilic addition, reduction, or condensation reactions. The tert-butyl group influences solubility and steric hindrance, which can be advantageous in controlling reaction selectivity.

Its applications are primarily concentrated in its role as a pharmaceutical intermediate. Notably, it is a key precursor in the synthesis of Ebastine, an antihistamine used for treating allergic conditions. The precise chemical structure of 4'-tert-Butyl-4-chlorobutyrophenone allows for efficient conversion into the target API, contributing to high yields and purity in the manufacturing process. For companies involved in Ebastine production, securing a reliable supply of this intermediate is essential for consistent manufacturing and competitive pricing.

Beyond specific API synthesis, this compound also serves as a versatile building block in broader fine chemical synthesis. Its ability to participate in various organic transformations makes it a valuable starting material for creating a range of complex organic molecules. Researchers and industrial chemists can leverage its unique structural features to develop novel compounds for diverse applications, from advanced materials to new therapeutic candidates. For those looking to purchase high-quality intermediates for their R&D or manufacturing needs, understanding these properties is the first step towards successful integration into their synthetic schemes.

In essence, the chemical profile of 4'-tert-Butyl-4-chlorobutyrophenone – its appearance, molecular structure, and inherent reactivity – positions it as a critical and sought-after compound in the chemical industry. As a leading manufacturer, we are committed to providing this essential intermediate with the highest standards of purity and quality, supporting your synthesis and procurement goals.