For chemists and researchers engaged in complex synthesis, a thorough understanding of a chemical intermediate's profile is indispensable. 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole (CAS No. 1231930-33-8) is a prime example of such a critical compound, particularly valued in the pharmaceutical sector for its role in creating advanced APIs like Abemaciclib.

At its core, this molecule is a substituted benzimidazole, featuring a bromine atom at the 6-position, a fluorine atom at the 4-position, a methyl group at the 2-position, and an isopropyl group attached to the nitrogen at the 1-position. Its molecular formula is C11H12BrFN2, with a molecular weight of approximately 271.13 g/mol. These structural elements are strategically positioned to facilitate specific chemical reactions and contribute to the efficacy of the final pharmaceutical product.

The physical and chemical properties provided by manufacturers are key indicators of quality. For 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole, typical specifications include an appearance of a white solid. Key physical parameters such as density (around 1.5 g/cm³) and boiling point (approximately 353.4 °C at 760 mmHg) offer further insights into its handling and behavior during synthesis. The flash point, often around 167.6 °C, is also a critical safety consideration.

Analytical confirmation of its structure and purity is paramount. Reputable manufacturers will provide data confirming the structural integrity through techniques like proton Nuclear Magnetic Resonance (H-NMR), which verifies the chemical shifts and coupling patterns of the hydrogen atoms, ensuring they match the reference standard. High-Performance Liquid Chromatography (HPLC) and Gas Chromatography-Mass Spectrometry (GC-MS) are employed to assess purity and confirm the molecular weight of the main peak and fragment ions, thus guaranteeing the absence of significant impurities. Inorganic salt content and loss on drying are typically kept below 0.1%, and heavy metal content is limited to ≤10 ppm, underscoring the high standards maintained by leading suppliers.

For R&D scientists looking to buy this intermediate, partnering with a manufacturer that provides detailed chemical profiles and comprehensive analytical data is essential for successful research and development. Understanding these properties ensures that you can effectively integrate 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole into your synthetic pathways, confident in its quality and performance.