Baclofen, known by its CAS number 1134-47-0, is a significant pharmaceutical compound primarily recognized for its role as a muscle relaxant. Understanding its chemical profile is fundamental for manufacturers, researchers, and formulators in the pharmaceutical industry. NINGBO INNO PHARMCHEM CO.,LTD. provides critical insights into the properties and potential synthesis of this vital chemical.

Chemically, Baclofen is identified as 4-amino-3-(4-chlorophenyl)butanoic acid. Its molecular formula is C10H12ClNO2, with a molecular weight of approximately 213.68 g/mol. Physically, Baclofen typically appears as a white to very faintly yellow solid. Key physical properties include a density of 1.285 g/cm³ and a boiling point of 364.3 °C at 760 mmHg. Its flash point is recorded at 174.1 °C. Solubility data indicates it is 1 M HCl soluble at 50 mg/mL, slightly soluble in water, very slightly soluble in methanol, and insoluble in chloroform.

The synthesis of Baclofen involves several chemical steps, often starting with readily available precursors. While specific patented synthesis routes vary, a common approach might involve reactions that build the butyric acid chain and incorporate the chlorophenyl group. For instance, reactions involving derivatives of cinnamic acid or related compounds could be employed, followed by amination and other functional group transformations. The precise route chosen by manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. often depends on factors such as cost-effectiveness, yield, purity, and environmental considerations.

The purity and consistency of Baclofen are paramount, especially for pharmaceutical applications. Manufacturers employ rigorous quality control measures, including analytical techniques such as High-Performance Liquid Chromatography (HPLC), Gas Chromatography (GC), and Nuclear Magnetic Resonance (NMR) spectroscopy, to ensure that the final product meets stringent pharmacopeial standards. These analyses confirm the chemical identity, assay, and impurity profile of the Baclofen produced.

As a key pharmaceutical intermediate, the reliable sourcing of high-quality Baclofen is essential for drug manufacturers worldwide. NINGBO INNO PHARMCHEM CO.,LTD. plays a crucial role in this supply chain, ensuring that this critical compound is available for the production of essential medications used to treat muscle spasticity and related conditions. Their commitment to chemical excellence underpins the availability of effective treatments.

Understanding the chemical profile of Baclofen not only aids in its production but also informs its application and handling. The physical and chemical properties directly influence formulation strategies, storage conditions, and potential interactions with other substances, making this knowledge indispensable for industry professionals.