In the intricate landscape of pharmaceutical synthesis, understanding the detailed chemical profile of intermediates is fundamental for successful drug development and manufacturing. Dimethyl 2-(2-methoxyphenoxy)malonate (CAS No.: 150726-89-9) is a prime example of such a crucial compound, primarily serving as a key intermediate in the synthesis of Bosentan. For R&D scientists and procurement managers alike, a thorough grasp of its properties, purity, and application is vital.

Dimethyl 2-(2-methoxyphenoxy)malonate is chemically identified as a malonic acid ester derivative. Its molecular formula is C12H14O6, and it has a molecular weight of 254.236 g/mol. The product is typically described as an off-white to yellow powder, with a specified purity of ≥98.0%. These specifications are critical. For researchers aiming to buy this compound for Bosentan synthesis, the high purity ensures that the subsequent reaction steps proceed efficiently and yield the desired pharmaceutical product with minimal contaminants. This is where the advantage of sourcing from a reliable manufacturer becomes apparent.

Beyond purity, key physical and chemical properties such as density (1.2±0.1 g/cm³), boiling point (320.5±27.0 °C at 760 mmHg), and flash point (138.4±23.8 °C) provide essential data for safe handling, storage, and reaction optimization. These parameters are crucial for laboratory scientists and chemical engineers involved in process development. A consistent supply of this intermediate, accompanied by accurate technical data, empowers R&D teams to scale up production effectively.

The primary application of Dimethyl 2-(2-methoxyphenoxy)malonate is its role as an intermediate in the synthesis of Bosentan. Bosentan is a dual endothelin receptor antagonist used to treat pulmonary arterial hypertension. The reliable availability of high-quality Dimethyl 2-(2-methoxyphenoxy)malonate from trusted suppliers directly impacts the accessibility and cost-effectiveness of Bosentan. Pharmaceutical companies looking to source this chemical should inquire about batch consistency and the availability of technical documentation to support their manufacturing processes.

In conclusion, Dimethyl 2-(2-methoxyphenoxy)malonate is a vital chemical entity in pharmaceutical synthesis, particularly for Bosentan production. Its chemical profile, marked by high purity and specific physical properties, makes it an indispensable component for both R&D and manufacturing. For those in the pharmaceutical sector seeking to purchase this intermediate, partnering with experienced chemical manufacturers and suppliers ensures access to quality materials at a competitive price, driving innovation and therapeutic advancements.