For scientists engaged in organic synthesis and pharmaceutical development, a thorough understanding of the chemical and physical properties of key intermediates is fundamental. 4-(3,4-Dichlorophenyl)-1-tetralone (CAS 79560-19-3) is a crucial compound, primarily recognized for its role in the Sertraline synthesis pathway. This article explores its characteristic properties, appearance, and essential handling considerations for research and manufacturing environments.

Chemical Identity and Structure

4-(3,4-Dichlorophenyl)-1-tetralone, with the molecular formula C16H12Cl2O and a molecular weight of approximately 291.17 g/mol, belongs to the tetralone class of compounds. The presence of the dichlorophenyl group and the tetralone ring system provides specific reactivity, making it a valuable intermediate in complex organic synthesis. Its structure is key to its function in building the Sertraline molecule.

Physical Properties: Appearance and Solubility

The typical appearance of 4-(3,4-Dichlorophenyl)-1-tetralone is a white to off-white solid. This physical state is consistent across most reputable suppliers. Information regarding its solubility often indicates it is slightly soluble in solvents like chloroform and methanol, particularly when heated or sonicated. Understanding solubility is vital for reaction planning and purification processes.

Key Specifications for Sourcing:

  • Purity: Generally specified as ≥98% (by GC or HPLC), which is critical for pharmaceutical applications to minimize impurities in the final API.
  • Melting Point: Reported values often fall within the range of 97-99°C, a key identifier for purity and batch consistency.
  • Storage Conditions: It is typically recommended to store this compound in a dry, dark, and well-ventilated place, with containers kept tightly closed, often at room temperature or refrigerated (e.g., 2-8°C) depending on supplier recommendations for optimal long-term stability.

Handling and Safety Considerations

As with all chemical reagents, appropriate safety precautions must be observed when handling 4-(3,4-Dichlorophenyl)-1-tetralone. This includes:

  • Wearing personal protective equipment (PPE) such as gloves, safety glasses, and lab coats.
  • Using the material in a well-ventilated area or under a chemical fume hood to avoid inhalation of dust or vapors.
  • Avoiding contact with skin and eyes.
  • Consulting the Material Safety Data Sheet (MSDS) provided by the manufacturer for detailed hazard information and emergency procedures.

For researchers and R&D scientists looking to buy 4-(3,4-Dichlorophenyl)-1-tetralone, understanding these properties ensures efficient and safe utilization in synthesis. We, as a dedicated supplier and manufacturer, provide comprehensive specifications and safety data to support your chemical needs.