For research and development scientists and product formulators, a deep understanding of chemical properties is crucial for successful application. Methyl 1H-1,2,4-Triazole-3-Carboxylate, identified by its CAS number 4928-88-5, is a compound that merits close examination due to its pivotal role in pharmaceutical synthesis, most notably as an intermediate for Ribavirin. Delving into its chemical profile helps R&D professionals determine its suitability for various synthetic pathways and formulation strategies.

The physical characteristics of Methyl 1H-1,2,4-Triazole-3-Carboxylate include its appearance as a white to off-white crystalline powder. This form factor is typical for many fine chemical intermediates, facilitating handling and storage. Its molecular formula is C4H5N3O2, with a molecular weight of approximately 127.101 g/mol. These basic identifiers are fundamental for any chemist working with the compound.

Key physical and chemical properties relevant to its use include its melting point, which is generally reported in the range of 196-199°C. This relatively high melting point indicates good thermal stability, a desirable trait for chemical intermediates that may undergo heating during synthesis or processing. The boiling point is significantly higher, around 283.9°C at 760 mmHg, suggesting low volatility under standard laboratory conditions. The flash point, typically above 120°C, also points to its safe handling characteristics.

Purity is a paramount concern in pharmaceutical intermediate sourcing. Reputable suppliers of Methyl 1H-1,2,4-Triazole-3-Carboxylate will provide specifications such as an assay of ≥98.0% by HPLC. Low loss on drying (≤0.5%) is another critical indicator of quality, ensuring that the compound is free from excessive moisture. These parameters are vital for scientists aiming to achieve reproducible results in their synthesis of Ribavirin or other complex molecules.

The reactivity of the triazole ring system within Methyl 1H-1,2,4-Triazole-3-Carboxylate makes it a versatile building block in organic synthesis. Its potential applications extend beyond Ribavirin, making it a valuable compound for exploring novel heterocyclic chemistry. For those looking to buy this intermediate, consulting with a reliable manufacturer or supplier in China can provide access to detailed technical data sheets and support for your R&D projects.