In the realm of organic chemistry, understanding the precise properties of chemical intermediates is vital for successful synthesis and product development. Methyl 5-bromo-2-fluorobenzoate (CAS: 57381-59-6) is one such compound, valued for its specific molecular structure and reactivity. This article provides a detailed look at its key chemical characteristics, handling considerations, and its significance for professionals seeking to purchase this essential intermediate.

Methyl 5-bromo-2-fluorobenzoate is characterized by the molecular formula C8H6BrFO2 and a molecular weight of approximately 233.03 g/mol. It typically appears as a white crystalline powder, a physical state that influences its handling and storage requirements. While specific melting point data may vary, its boiling point is predicted to be around 254.0 ± 25.0 °C, and its density is approximately 1.577 ± 0.06 g/cm³. These physical parameters are important for process engineers and chemists designing reaction conditions and purification protocols.

The compound's structure includes a benzene ring substituted with a bromine atom, a fluorine atom, and a methyl ester group. This arrangement of functional groups makes it a versatile reagent in various organic transformations. The presence of bromine and fluorine atoms allows for nucleophilic substitution reactions, cross-coupling reactions (like Suzuki or Sonogashira couplings), and other synthetic strategies. The methyl ester can also be readily hydrolyzed to the corresponding carboxylic acid or further modified.

For those aiming to buy Methyl 5-bromo-2-fluorobenzoate, understanding its safety profile is crucial. Standard hazard statements often include indications of skin and eye irritation, and potential respiratory tract irritation. Therefore, appropriate personal protective equipment (PPE), such as gloves, eye protection, and lab coats, should always be used when handling the material. Proper ventilation is also recommended. Information on storage conditions typically suggests keeping it sealed in a dry environment at room temperature to maintain its stability and purity.

As a key intermediate, particularly in the synthesis of pharmaceuticals like progesterone, the quality of Methyl 5-bromo-2-fluorobenzoate is paramount. Customers looking to procure this chemical should seek out suppliers who can provide comprehensive technical data, including purity analysis and spectral data. Direct engagement with a manufacturer, especially one based in China, can offer advantages in terms of competitive pricing and direct access to product expertise. It’s advisable to request samples to verify quality before placing larger orders.

In conclusion, Methyl 5-bromo-2-fluorobenzoate is a compound with a well-defined chemical profile that makes it invaluable in advanced organic synthesis. By understanding its properties, safety requirements, and procurement channels, chemists and procurement specialists can effectively leverage this intermediate for their research and production needs, ensuring efficient and successful outcomes.