For professionals in the pharmaceutical and chemical industries, understanding the intrinsic properties of a compound is crucial for successful application. 6-Methoxyguanine (CAS 20535-83-5), a vital pharmaceutical intermediate, possesses a specific set of chemical and physical characteristics that underpin its utility, particularly in the synthesis of complex molecules like nelarabine.

Molecular Structure and Identity: At its core, 6-Methoxyguanine is a derivative of guanine, one of the fundamental bases in DNA. Its chemical formula is C6H7N5O, with a molecular weight of approximately 165.15 g/mol. This molecular structure features a purine ring system with an amino group at the 2-position and a methoxy group (-OCH3) at the 6-position. Its unique arrangement is what makes it a sought-after building block in organic synthesis. Synonyms such as 2-Amino-6-methoxypurine and 6-Methoxyguanine are commonly used, and understanding these interchangeably helps in research and procurement.

Physical Characteristics and Purity Standards: In its pure form, 6-Methoxyguanine typically presents as a white to off-white crystalline powder. This solid state is a convenient form for handling and storage in laboratory and manufacturing settings. The physical form is often a good initial indicator of purity. Crucially for pharmaceutical applications, the purity standards are rigorously defined. Our specifications for 6-Methoxyguanine include an assay of ≥99.0% as measured by High-Performance Liquid Chromatography (HPLC), ensuring minimal presence of related impurities. Furthermore, a low loss on drying (≤0.5%) signifies minimal water content, contributing to product stability and accurate weighing for reactions. A low residue on ignition (≤0.1%) indicates a low inorganic salt content, which is vital for sensitive synthetic processes.

Thermal and Solubility Properties: The thermal stability of 6-Methoxyguanine is notable; its melting point is reported as >300ºC, often accompanied by decomposition, suggesting it is robust under standard processing temperatures. Its flash point of 315.8ºC indicates a low flammability risk under normal conditions. While solubility data can vary, it is generally soluble in polar organic solvents like DMSO, and slightly soluble in water, often requiring heated conditions for better dissolution. These properties inform handling, storage, and reaction solvent selection.

Regulatory and Safety Information: Compounds like 6-Methoxyguanine are subject to safety regulations. While not extensively detailed in the provided material beyond hazard codes (e.g., Xi for irritant), standard safety precautions for handling fine chemicals should always be observed, including the use of personal protective equipment (PPE) and working in well-ventilated areas. Its primary CAS number, 20535-83-5, ensures accurate identification in chemical databases and regulatory filings.

Application Relevance: These detailed chemical and physical properties are not merely academic. They directly influence how 6-Methoxyguanine performs as an intermediate. Its molecular structure facilitates the specific bond formations required for nelarabine synthesis, while its high purity and stability ensure reproducible reaction outcomes and a high-quality final drug product. As a manufacturer and supplier, we ensure these critical properties are consistently met, providing our clients with a reliable foundation for their pharmaceutical development and manufacturing.

Understanding the chemical profile of 6-Methoxyguanine empowers researchers and manufacturers to make informed decisions, optimize synthesis processes, and ensure the quality and safety of the final pharmaceutical products. We are dedicated to providing this compound with the precise characteristics demanded by the industry.