In the realm of pharmaceutical synthesis, understanding the precise chemical profile of intermediates is fundamental to successful API production. This article provides a detailed overview of Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1H-imidazole-5-carboxylate, identified by CAS number 144689-93-0. This compound is a critical component in the manufacturing pathway of Olmesartan Medoxomil, a widely utilized medication for cardiovascular health.

The chemical structure of Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1H-imidazole-5-carboxylate features a substituted imidazole ring. Key identifiers include its molecular formula, C12H20N2O3, and a molecular weight of approximately 240.30 g/mol. As a pharmaceutical intermediate, its physical appearance is typically a white powder, indicating a solid state at room temperature which is advantageous for handling and storage in manufacturing settings. The specified purity levels, often 98% or higher, are crucial for ensuring the efficacy and safety of the final drug product.

While specific physical properties like melting point are detailed in technical documentation, the chemical reactivity is what makes this intermediate so valuable. The presence of the ester group and the tertiary alcohol on the imidazole ring allows for specific transformations required in the multi-step synthesis of Olmesartan. For those looking to buy this compound, understanding its chemical behavior within a reaction sequence is paramount.

The synthesis of Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1H-imidazole-5-carboxylate itself involves sophisticated organic chemistry. Typically, it can be prepared through reactions involving Grignard reagents and appropriate imidazole precursors. Manufacturers meticulously control reaction conditions, purification steps, and analytical testing to ensure the final product meets stringent pharmaceutical standards. This rigorous approach is why pharmaceutical companies often seek out specialized manufacturers, particularly in regions like China, known for their chemical synthesis expertise and competitive pricing.

When sourcing this intermediate, industry professionals often search for terms like 'buy CAS 144689-93-0', 'Olmesartan intermediate manufacturer', or 'high purity imidazole derivative supplier'. These searches highlight the demand for reliable chemical suppliers who can provide not only the compound itself but also comprehensive technical data, such as spectral analysis (NMR, IR, Mass Spectrometry) and chromatograms (HPLC, GC) to confirm purity and identity. A robust Certificate of Analysis (COA) is a standard requirement.

In conclusion, Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1H-imidazole-5-carboxylate (CAS 144689-93-0) is a vital cog in the pharmaceutical manufacturing machine. Its precise chemical profile and purity are critical for the successful synthesis of Olmesartan Medoxomil. As a dedicated manufacturer and supplier, we provide this essential intermediate with the quality and reliability that the pharmaceutical industry demands. Contact us to discuss your requirements and obtain a competitive quote.