For research and development scientists, a deep understanding of the chemical profile of compounds like Quetiapine Fumarate (CAS 111974-72-2) is fundamental to successful drug discovery and development. This intermediate, while known for its pharmaceutical applications, possesses chemical characteristics that are vital for synthetic chemists and formulation scientists to comprehend. From its molecular structure to its reactivity, exploring these aspects provides valuable insights for anyone looking to purchase or utilize this compound effectively.

Chemical Structure and Properties
Quetiapine Fumarate is the fumarate salt of quetiapine. The molecular formula is C46H54N6O8S2, and its CAS number is 111974-72-2. It typically presents as a white to off-white solid. Its solubility characteristics in various solvents are important for reaction design and formulation. For instance, its solubility in DMSO and water, as indicated in technical data, plays a role in its handling and processing. Understanding these properties helps researchers in designing efficient synthetic routes and stable formulations.

Reactivity and Synthesis Pathways
As a pharmaceutical intermediate, Quetiapine Fumarate is designed to undergo specific chemical transformations to yield the final active pharmaceutical ingredient. While detailed proprietary synthesis pathways are not always publicly disclosed, its structure suggests common reaction types involved in forming amine-based heterocycles. Chemists aiming to buy Quetiapine Fumarate often seek it as a convenient starting point, leveraging its pre-formed structural elements to reduce the complexity and number of steps in their synthesis. The fumarate salt form itself contributes to stability and handling properties compared to the free base.

Analytical Characterization and Quality Control
The purity of Quetiapine Fumarate is critical. Analytical techniques such as High-Performance Liquid Chromatography (HPLC), Mass Spectrometry (MS), and Nuclear Magnetic Resonance (NMR) spectroscopy are routinely employed by manufacturers to verify its identity and purity. Researchers utilizing Quetiapine Fumarate will often rely on the supplier's Certificate of Analysis (CoA) to confirm that the material meets the required specifications. For R&D purposes, understanding potential impurities and their impact on downstream reactions is also crucial. When sourcing, always inquire about the analytical methods used and the typical impurity profile provided by the manufacturer or supplier.

Applications and Further Research
While primarily recognized as an intermediate for antipsychotic medications, the chemical properties of Quetiapine Fumarate can also be explored in other research contexts. For example, its interaction with various receptors and its metabolic pathways have been subjects of extensive study. Pharmaceutical companies looking to purchase Quetiapine Fumarate often do so for its established role in synthesizing specific APIs, but the compound itself, or derivatives thereof, might also be investigated for novel therapeutic targets or as tool compounds in biochemical assays. The availability of this intermediate from reliable chemical suppliers facilitates ongoing research and innovation in the pharmaceutical sciences.