For professionals in the chemical and pharmaceutical sectors, a thorough understanding of a compound's properties is fundamental to its successful application and procurement. This article delves into the key chemical and physical characteristics of 1-(4-Fluorophenyl)piperazine, identified by CAS number 2252-63-3, a vital intermediate in many synthetic processes. As a leading chemical supplier, we aim to provide clear and accurate information to support your research and purchasing decisions.

Chemical Identity and Structure
1-(4-Fluorophenyl)piperazine, also known by synonyms such as N-(p-Fluorophenyl)piperazine or p-Fluorophenylpiperazine, possesses the molecular formula C10H13FN2. Its molecular weight is approximately 180.22 g/mol. The compound's structure consists of a piperazine ring linked to a phenyl ring substituted with a fluorine atom at the para position. This structural arrangement imparts specific reactivity and properties that make it a valuable intermediate in organic synthesis.

Physical Properties of Note
Understanding the physical state and behavior of 1-(4-Fluorophenyl)piperazine is crucial for handling, storage, and application:

  • Appearance: Typically described as a clear yellowish liquid after melting. Its melting point is generally reported to be in the range of 30-33°C, indicating it may exist as a solid at standard room temperatures but readily melts into a liquid.
  • Boiling Point: The boiling point is significantly high, often cited around 118-123°C at a reduced pressure of 0.1 mmHg. At atmospheric pressure (760 mmHg), it boils at approximately 363.6°C, with a flash point exceeding 230°F (or 137.8°C at 760 mmHg).
  • Solubility: It exhibits slight solubility in organic solvents like chloroform and ethyl acetate, making it compatible with many common reaction media. However, it is insoluble in water.
  • Density: Its density is approximately 1.112 g/cm³ (as indicated by one source) or around 1.0 (as per others), which is useful for volume-to-mass conversions in laboratory settings.
  • Refractive Index: The refractive index is typically in the range of 1.5585-1.5605, a parameter often used for quality verification.
  • Stability and Sensitivity: 1-(4-Fluorophenyl)piperazine is noted to be air-sensitive and should be stored under appropriate conditions to maintain its integrity.

Key Reactivity Aspects
As a secondary amine within the piperazine ring, 1-(4-Fluorophenyl)piperazine can undergo various reactions, including alkylation and acylation. The presence of the fluorine atom on the phenyl ring can also influence its electronic properties and reactivity in electrophilic aromatic substitution reactions, although this is less common given the nucleophilic nature of the piperazine nitrogen.

Procuring 1-(4-Fluorophenyl)piperazine with guaranteed purity and consistent physical properties is vital for its effective use. We, as a dedicated supplier, ensure that our product meets these stringent requirements, providing you with the confidence needed for your chemical synthesis projects. For detailed specifications and bulk purchase inquiries, feel free to contact our sales team.