For professionals in the pharmaceutical industry, a deep understanding of chemical intermediates is crucial for successful drug synthesis and quality control. This article delves into the important chemical properties and specifications of 1-(6-Methylpyridin-3-yl)-2-[4-(methylsulfonyl)phenyl]ethanone, CAS No. 221615-75-4, a vital intermediate for Etoricoxib production. As a leading supplier, we provide insights that are essential for procurement managers and R&D scientists.

The compound, also known as Ketosulfone, has a molecular formula of C15H15NO3S and a molecular weight of approximately 289.35 g/mol. Its physical appearance is typically a white crystalline powder, which is a critical indicator for handling and quality assessment in pharmaceutical manufacturing. The physical and chemical properties, such as density (1.2±0.1 g/cm³) and a high flash point (262.1±30.1 °C), suggest a stable compound under standard storage conditions, which is vital for maintaining its integrity throughout the supply chain and manufacturing process.

Key specifications for this pharmaceutical intermediate include a purity level of ≥99.0%. This high purity is non-negotiable for its intended use in Etoricoxib synthesis and as an impurity reference standard. Additional specifications often include a low heavy metal content (≤10ppm), minimal residue on ignition (≤0.2%), and tight control over single and total impurities (≤0.2% and ≤1.0%, respectively). A low loss on drying (≤0.5%) also indicates its stability and proper handling.

The primary application of 1-(6-Methylpyridin-3-yl)-2-[4-(methylsulfonyl)phenyl]ethanone is as an intermediate in the synthesis of Etoricoxib, a selective COX-2 inhibitor used for its anti-inflammatory and analgesic properties. Its presence as a potential impurity necessitates its use as a reference standard in quality control laboratories for analytical method development, validation, and routine testing. This ensures that the final Etoricoxib product meets all regulatory purity requirements.

When sourcing this compound, it is imperative to partner with a reliable manufacturer and supplier that can provide detailed technical data and consistent product quality. We are committed to supplying high-grade 1-(6-Methylpyridin-3-yl)-2-[4-(methylsulfonyl)phenyl]ethanone, backed by robust quality assurance. Understanding these chemical properties and specifications allows pharmaceutical professionals to make informed decisions, ensuring the efficacy and safety of their final drug products.