In the intricate world of pharmaceutical development, understanding the precise chemical properties of intermediates is non-negotiable. 1,2-Benzisothiazol-3(2H)-one, bearing the CAS number 2634-33-5, stands out as a crucial heterocyclic compound widely utilized in the synthesis of various Active Pharmaceutical Ingredients (APIs), most notably Ziprasidone. For R&D scientists and process chemists, a thorough grasp of its characteristics ensures successful synthetic routes and product quality.

The physical state of 1,2-Benzisothiazol-3(2H)-one is typically described as a white to light yellow powder. This appearance is often accompanied by a defined melting point range, usually between 154-158°C, which serves as a key indicator of its purity. With a molecular formula of C7H5NOS and a molecular weight of approximately 151.19 g/mol, this compound possesses a specific structure that makes it an ideal building block. Its solubility in common organic solvents like dichloromethane and dimethyl sulfoxide further facilitates its integration into various reaction conditions, a vital aspect for chemists optimizing synthetic processes.

The significance of 1,2-Benzisothiazol-3(2H)-one in pharmaceutical research and development cannot be overstated. Its primary role as an intermediate in the production of Ziprasidone, an important antipsychotic medication, highlights its value. Pharmaceutical companies looking to buy this compound are primarily interested in its purity (typically specified as ≥98%), which directly impacts the downstream synthesis and the final API’s impurity profile. A reliable supplier or manufacturer in China, for example, can provide this material with the necessary quality assurance, often accompanied by detailed technical data sheets and Certificates of Analysis.

For procurement professionals, sourcing this intermediate requires careful consideration of chemical suppliers. It is essential to find a manufacturer that can guarantee not only the stated purity but also a consistent supply. The ability to obtain a quote for bulk quantities or discuss specific quality requirements is a hallmark of a reputable supplier. Whether for initial research phases or large-scale production, securing a dependable source for 1,2-Benzisothiazol-3(2H)-one is key to efficient drug development and manufacturing.

In summary, the chemical properties of 1,2-Benzisothiazol-3(2H)-one—its physical form, melting point, solubility, and high purity—make it an indispensable intermediate in pharmaceutical synthesis. For R&D departments and manufacturing units, partnering with trusted chemical suppliers and manufacturers is crucial for accessing this compound and driving innovation in drug development.