For synthetic chemists and medicinal chemists engaged in pharmaceutical R&D, understanding the detailed chemical properties of key building blocks is fundamental. 2,3-Difluoro-L-Tyrosine (CAS 182756-49-6) represents a class of fluorinated amino acid derivatives that are increasingly sought after for their potential to modulate drug candidate properties. This article delves into the chemical characteristics of this compound and its significance in research settings.

Chemical Structure and Properties

The core structure of 2,3-Difluoro-L-Tyrosine is derived from L-Tyrosine, with fluorine atoms substituted at the 2 and 3 positions of the phenolic ring. This fluorination has several implications:

  • Increased Lipophilicity: Fluorine atoms can increase the lipophilicity of a molecule, potentially improving membrane permeability and oral bioavailability of drug candidates.
  • Altered Electronic Properties: The electronegativity of fluorine influences the electron distribution in the phenyl ring, affecting reactivity and interactions with biological targets.
  • Enhanced Metabolic Stability: The carbon-fluorine bond is one of the strongest single bonds in organic chemistry, often making fluorinated compounds more resistant to metabolic degradation.
  • Acidity (pKa): Understanding the pKa values of the carboxylic acid and amino groups is crucial for predicting ionization states at physiological pH and for designing buffer systems in assays.
  • Boiling Point and Flash Point: While primarily a solid, these parameters offer insights into its thermal stability and handling safety. The reported boiling point of 368.181°C at 760 mmHg and flash point of 176.47°C highlight its relative stability under normal conditions.

Synthesis and Sourcing Considerations

The synthesis of such fluorinated intermediates typically involves multi-step organic reactions, requiring specialized expertise. For researchers and development teams, the most efficient approach is often to source the compound from specialized chemical suppliers. When you are looking to buy 2,3-Difluoro-L-Tyrosine, consider the following:

  • Purity: High purity (≥99%) is essential for reproducible research outcomes.
  • Supplier Reliability: Partnering with a trusted 2,3-Difluoro-L-Tyrosine manufacturer or supplier in China ensures consistent quality and timely delivery.
  • Technical Support: Access to technical data sheets and support can be invaluable for R&D scientists.

As a key player in supplying specialty chemicals, we provide high-quality 2,3-Difluoro-L-Tyrosine to support your research and development endeavors. Understanding the specific chemical properties allows scientists to strategically incorporate this compound into new molecular designs, potentially leading to breakthroughs in therapeutic areas.

For R&D departments requiring this advanced amino acid derivative, it is important to establish relationships with reliable suppliers who can guarantee the quality and consistency needed for cutting-edge research.