For chemists and researchers engaged in the synthesis of complex organic molecules, a thorough understanding of the properties of their starting materials and intermediates is fundamental. 2-Bromo-5-fluoronitrobenzene, identified by CAS number 446-09-3, is a compound of significant interest due to its versatile chemical nature. As a manufacturer and supplier of this key intermediate, we aim to provide valuable insights into its characteristics, synthesis, and safe handling.

Key Chemical Properties of 2-Bromo-5-fluoronitrobenzene

2-Bromo-5-fluoronitrobenzene (CAS 446-09-3) possesses a unique combination of functional groups that dictate its reactivity and applications:

  • Molecular Formula: C6H3BrFNO2
  • Molecular Weight: Approximately 220.00 g/mol
  • Appearance: Typically described as a white to yellow or greenish powder. Its physical state can vary slightly depending on purity and temperature.
  • Melting Point: Reported values are generally in the range of 37-39°C, indicating it is a solid at standard room temperature but can melt easily.
  • Boiling Point: Often cited around 148-150°C at 35 mmHg, suggesting relatively low volatility under atmospheric pressure.
  • Solubility: Generally soluble in common organic solvents like ethyl acetate, DMSO, and toluene, but poorly soluble in water.
  • Reactivity: The bromine atom is activated by the electron-withdrawing nitro group, making it susceptible to nucleophilic aromatic substitution (SNAr) reactions. The nitro group can be reduced to an amine, and the fluorine atom can also be involved in specific reactions or remain as a functional element.

Synthesis and Manufacturing Considerations

The synthesis of 2-Bromo-5-fluoronitrobenzene can be achieved through various routes. A common method involves the bromination of fluoronitrobenzene derivatives. For example, referencing chemical literature, one synthesis involves starting materials like 4-fluoro-2-nitrobenzoic acid. Manufacturers optimize these processes for yield, purity, and cost-effectiveness. When you buy CAS 446-09-3, understanding that it comes from carefully controlled synthetic processes is essential.

Handling and Safety Precautions

As with many halogenated nitroaromatic compounds, 2-Bromo-5-fluoronitrobenzene requires careful handling. Safety data sheets (SDS) indicate it can be harmful if swallowed, inhaled, or absorbed through the skin, and may cause skin and eye irritation. Proper personal protective equipment (PPE), including gloves, safety glasses, and lab coats, should always be worn. Work should be conducted in a well-ventilated area or fume hood. Storage should be in a cool, dry place, tightly sealed, away from incompatible materials.

Why Source from a Reliable Manufacturer?

When procuring 2-Bromo-5-fluoronitrobenzene (CAS 446-09-3), partnering with a trusted manufacturer ensures you receive a product that meets specifications and is handled with appropriate safety measures. Our company is dedicated to providing high-quality intermediates, backed by comprehensive technical data and a commitment to customer satisfaction. We aim to be your preferred supplier for essential chemical building blocks.