For chemists and R&D professionals, a thorough understanding of a chemical's properties is fundamental to its effective utilization. 2-Bromo-6-chloro-benzonitrile (CAS: 6575-08-2) is a compound whose structural features dictate its reactivity and applicability in various synthetic processes. This article provides an overview of its key chemical characteristics and highlights the importance of sourcing it from reliable suppliers.

The molecular formula of 2-Bromo-6-chloro-benzonitrile is C7H3BrClN, with a molecular weight of approximately 216.46 g/mol. Structurally, it is a benzonitrile derivative substituted with a bromine atom at the 2-position and a chlorine atom at the 6-position relative to the nitrile group. The presence of these electron-withdrawing halogens, in addition to the nitrile group, influences the electron density distribution within the aromatic ring. This electronic configuration makes the compound susceptible to various nucleophilic aromatic substitution reactions, although the steric hindrance from the ortho-substituents can also play a role in reaction kinetics.

The reactivity of 2-Bromo-6-chloro-benzonitrile is particularly noted in palladium-catalyzed cross-coupling reactions. The carbon-bromine bond is generally more reactive than the carbon-chlorine bond in these types of transformations, allowing for selective functionalization. This difference in reactivity can be exploited to introduce different substituents sequentially, providing a pathway to highly functionalized molecules. Furthermore, the nitrile group (-C≡N) can undergo hydrolysis to form carboxylic acids or amides, reduction to amines, or participate in cycloaddition reactions, adding to its synthetic utility.

When you are looking to buy 2-Bromo-6-chloro-benzonitrile for your research or production needs, it is crucial to ensure its purity. NINGBO INNO PHARMCHEM CO.,LTD. is a prominent manufacturer and supplier in China, offering this compound with a high purity of 97%+. We are committed to providing chemists with reliable access to quality reagents, ensuring that your synthetic strategies can be implemented with confidence. Our competitive pricing and consistent product quality make us an excellent choice for sourcing essential chemical intermediates. Partner with NINGBO INNO PHARMCHEM for your chemical supply needs and experience the difference quality makes.