In the realm of pharmaceutical chemistry, understanding the precise properties of chemical intermediates is fundamental to successful drug synthesis. 2-Chloro-1,4-Naphthoquinone, identified by CAS number 1010-60-2, is a prime example of such a critical compound. This yellow crystalline solid is not merely a reagent; it's a meticulously crafted building block essential for producing life-saving medications, most notably Atovaquone, a cornerstone in treating malaria and other parasitic infections. As a leading manufacturer and supplier, our aim is to provide clarity on its characteristics and applications.

The chemical identity of 2-Chloro-1,4-Naphthoquinone is defined by its molecular formula, C10H5ClO2, and a molecular weight of approximately 192.60 g/mol. Its structure features a naphthoquinone core with a chlorine atom at the 2-position, a feature that dictates its reactivity in subsequent synthesis steps. Physically, it presents as a yellow solid, a characteristic that aids in its identification and quality assessment. While specific physical properties can vary slightly between batches, typical characteristics include a melting point around 108-109°C, and a density of approximately 1.42 g/cm³.

The utility of 2-Chloro-1,4-Naphthoquinone as a pharmaceutical intermediate stems from its role in forming the core structure of Atovaquone. Atovaquone functions by disrupting the mitochondrial electron transport chain in protozoa, effectively inhibiting their energy production. The synthesis pathway leverages the specific chemical functionalities of 2-Chloro-1,4-Naphthoquinone to construct this vital therapeutic molecule. Therefore, when purchasing this compound, ensuring high purity (typically ≥99.0%) and minimal impurities is critical for process efficiency and final product quality. Manufacturers in China are increasingly focused on meeting these exacting standards.

For research scientists and procurement managers, identifying a reliable 2-Chloro-1,4-Naphthoquinone supplier in China is key. A reputable manufacturer will not only provide detailed technical data but also ensure stable supply and competitive pricing for bulk quantities. The stability of this compound, when stored correctly in well-closed, dry, and cool conditions, further adds to its appeal for long-term storage and use in manufacturing. By understanding these chemical properties, pharmaceutical professionals can confidently source and utilize 2-Chloro-1,4-Naphthoquinone for their critical synthesis needs.