For chemists and procurement specialists in the fine chemical and pharmaceutical sectors, a deep understanding of chemical intermediates is crucial. 2-Chloro-3-hydroxy-4-methoxybenzaldehyde (CAS 37687-57-3) is a compound of significant interest due to its utility in synthesizing complex organic molecules. This article explores its key chemical properties, common synthesis routes, and the importance of sourcing from reliable manufacturers.

Chemical Profile and Properties

2-Chloro-3-hydroxy-4-methoxybenzaldehyde, with the molecular formula C8H7ClO3 and a molecular weight of approximately 186.59 g/mol, presents a distinctive structure featuring an aldehyde group, a hydroxyl group, a methoxy group, and a chlorine atom on a benzene ring. Its key properties include:

  • Appearance: Typically a white to off-white crystalline powder.
  • Purity: High purity, usually specified as ≥99.0%, is essential for its applications.
  • Melting Point: Approximately 204-208 °C, indicating a relatively stable solid form at room temperature.
  • Reactivity: The presence of the aldehyde group makes it susceptible to oxidation and reduction reactions, while the hydroxyl group can participate in esterification or etherification. The chlorine atom and methoxy group also influence its electronic properties and reactivity.

Synthesis and Manufacturing Considerations

The synthesis of 2-Chloro-3-hydroxy-4-methoxybenzaldehyde often involves the chlorination of isovanillin. A common method described in chemical literature involves reacting isovanillin with a chlorinating agent like tert-butyl hypochlorite in acetic acid. Successful synthesis requires careful control of reaction conditions to ensure high yield and purity, minimizing the formation of unwanted by-products.

For businesses looking to buy 2-Chloro-3-hydroxy-4-methoxybenzaldehyde, selecting a manufacturer that excels in controlled synthesis processes is paramount. This ensures that the procured material meets the stringent requirements for its use as a pharmaceutical intermediate or a fragrance ingredient. Understanding the manufacturing process helps in evaluating the reliability and consistency of the supplier.

Why Source from a Trusted Supplier?

When you need to source this chemical, inquire about the price of 2-Chloro-3-hydroxy-4-methoxybenzaldehyde from reputable suppliers. Key advantages of partnering with an established 2-Chloro-3-hydroxy-4-methoxybenzaldehyde supplier include:

  • Consistent Quality: Reliable manufacturers maintain strict quality control, ensuring the product meets all specified parameters.
  • Technical Data: Access to detailed technical data, including COAs and safety data sheets (SDS), is crucial for safe handling and effective application.
  • Supply Chain Stability: Established companies can guarantee a consistent and reliable supply, supporting your production schedules.

By focusing on these chemical properties and sourcing considerations, companies can make informed decisions when procuring 2-Chloro-3-hydroxy-4-methoxybenzaldehyde, ensuring the success of their synthetic endeavors.