For chemists and product formulators, a thorough understanding of a chemical intermediate's properties is fundamental to its effective utilization. 3-Chloro-2-fluoropyridine, a widely used compound in fine chemical synthesis, offers a unique set of characteristics that make it a valuable component in various industrial applications, particularly in pharmaceuticals and agrochemicals.

3-Chloro-2-fluoropyridine, with the CAS number 1480-64-4, is typically supplied as a colorless liquid. Its molecular formula is C5H3ClFN, and it has a molecular weight of approximately 131.54 g/mol. Key physical and chemical properties include a density of around 1.33 g/cm³ and a boiling point of approximately 162 °C at standard atmospheric pressure. The refractive index is noted to be around 1.503, which is relevant for analytical purposes during synthesis and quality control.

The presence of both a chlorine atom and a fluorine atom on the pyridine ring imparts specific reactivity to 3-Chloro-2-fluoropyridine. These halogens can participate in various nucleophilic substitution and cross-coupling reactions, allowing for the facile introduction of diverse functional groups. This versatility makes it an ideal intermediate for constructing complex molecular architectures. For example, it can be used in Suzuki, Sonogashira, or Buchwald-Hartwig coupling reactions to form new carbon-carbon or carbon-heteroatom bonds.

In terms of applications, the compound is primarily employed as a pharmaceutical intermediate. It serves as a crucial starting material for synthesizing active pharmaceutical ingredients (APIs) that target a range of diseases. Its role extends to the agrochemical sector, where it aids in the development of next-generation crop protection agents. When seeking to purchase 3-Chloro-2-fluoropyridine, buyers often look for suppliers in China due to the country's strong chemical manufacturing capabilities and competitive pricing. Ensuring the purity meets specifications, often ≥98.0%, is vital for these applications.

Professionals looking to buy 3-Chloro-2-fluoropyridine for their synthesis needs should consult detailed product specifications and safety data sheets. Understanding these properties ensures that the material is handled and used safely and effectively, maximizing its potential as a chemical building block. Partnering with a reputable manufacturer can guarantee the quality and availability of this important intermediate.