For chemists and procurement professionals in the B2B chemical sector, a thorough understanding of a compound's properties is fundamental to its successful application and sourcing. 4-Acetylbenzonitrile, identified by CAS number 1443-80-7, is a molecule of significant interest due to its versatile chemical nature. This aromatic nitrile derivative, featuring both a nitrile group (-CN) and an acetyl group (-COCH3) at para positions on a benzene ring, offers a unique combination of reactivity that drives its utility in various synthetic processes.

Physically, 4-Acetylbenzonitrile typically appears as an off-white to pale yellow crystalline powder or mass, with a melting point generally ranging from 55-59°C. Its solubility profile indicates it is soluble in common organic solvents like chloroform and acetone but insoluble in water. This characteristic influences handling, storage, and reaction medium selection. The molecular formula C9H7NO and a molecular weight of approximately 145.16 g/mol are key identifiers for this compound.

Chemically, the presence of the electron-withdrawing nitrile group and the electrophilic carbonyl carbon in the acetyl group makes 4-Acetylbenzonitrile a reactive intermediate. It can undergo various reactions, including nucleophilic additions to the carbonyl group, reactions involving the alpha-hydrogens adjacent to the carbonyl, and transformations of the nitrile group. These properties enable its use as a building block for more complex molecules, including pharmaceutical APIs and agrochemical compounds. Its stability under various reaction conditions, as often noted by manufacturers and suppliers, is a critical advantage for process chemists.

When procuring 4-Acetylbenzonitrile, understanding these chemical and physical properties allows buyers to make informed decisions. For instance, knowing its solubility helps in selecting appropriate solvents for reactions or purification. Its melting point provides a quick check for purity, and its reactivity profile guides its application in synthesis. Reputable manufacturers often provide detailed technical data sheets that elaborate on these properties, ensuring that users can effectively integrate this versatile chemical into their operations. If you are looking to purchase this intermediate, consider manufacturers that provide comprehensive property data to ensure optimal results in your synthesis projects.