For chemists and material scientists, a thorough understanding of a chemical intermediate's properties is fundamental to its effective application. 4-Hydroxyphthalonitrile (CAS 30757-50-7) is a compound that, while seemingly simple, possesses a rich chemical profile making it invaluable in various synthetic endeavors. This article explores its key chemical characteristics, structure, and reactivity, providing insights for those looking to procure and utilize it effectively.

Structurally, 4-Hydroxyphthalonitrile is an aromatic compound belonging to the phthalonitrile family. Its chemical formula is C8H4N2O, and it features a benzene ring substituted with two nitrile (-C≡N) groups at adjacent positions (1 and 2) and a hydroxyl (-OH) group at position 4. This arrangement is crucial to its reactivity. The electron-withdrawing nature of the nitrile groups influences the electron density of the aromatic ring, while the hydroxyl group offers a site for nucleophilic or electrophilic attack, as well as hydrogen bonding.

Key physical properties often cited include its appearance as a white to light yellow powder, a melting point around 218°C, and a boiling point of approximately 394.6°C at atmospheric pressure. These characteristics suggest a relatively stable solid compound under ambient conditions, suitable for handling and storage. Its purity, often specified as 98% or higher by HPLC, is a critical factor for many applications, especially in pharmaceutical synthesis and the production of high-performance materials.

The reactivity of 4-Hydroxyphthalonitrile is primarily governed by its functional groups. The nitrile groups are susceptible to nucleophilic attack and are famously used in the cyclotetramerization reaction to form phthalocyanines. This reaction, often catalyzed by metal salts, leads to the formation of large, planar macrocycles that are intensely colored and possess unique electronic properties. The hydroxyl group is acidic due to its phenolic nature and can be deprotonated to form a phenoxide ion, which is a stronger nucleophile. It can also undergo reactions like etherification or esterification, allowing for further functionalization of molecules derived from 4-Hydroxyphthalonitrile.

For professionals seeking to buy 4-hydroxyphthalonitrile, understanding these properties is essential for selecting the right supplier and ensuring the material's suitability for their specific synthetic pathway. When inquiring about CAS 30757-50-7 price, it is advisable to also discuss purity specifications and analytical methods. Whether you are a researcher looking to synthesize novel compounds or a manufacturer aiming for cost-effective production, partnering with a reliable manufacturer that can provide detailed specifications and consistent quality is key. Requesting a quote based on your exact needs will facilitate informed procurement decisions.