For chemists and formulators working in research and development, a deep understanding of chemical properties is fundamental to successful synthesis and product development. 4-Methylpyridin-2-amine (CAS: 695-34-1) is an organic compound whose unique characteristics make it a valuable asset in various chemical applications, particularly as a synthesis intermediate. This article aims to explore its key physical and chemical properties, providing insights for professionals looking to buy this compound from a reliable supplier.

Key Physical Characteristics
4-Methylpyridin-2-amine, with the molecular formula C6H8N2, typically presents as a white to yellow powder or crystalline solid at room temperature. Its melting point is generally reported in the range of 96-99°C, and its boiling point is around 227.4°C at 760 mmHg. These physical attributes are important considerations for handling, storage, and reaction design. The compound's appearance can range from white to pale yellow or even light brown, depending on its purity and any minor oxidation or degradation that may have occurred during storage. Its hygroscopic nature means it should be stored under dry conditions, ideally under an inert atmosphere, to maintain its purity and prevent degradation.

Chemical Reactivity and Applications
Chemically, 4-Methylpyridin-2-amine is a pyridine derivative featuring an amino group at the 2-position and a methyl group at the 4-position. The nitrogen atom in the pyridine ring and the amino group provide sites for various chemical reactions, including nucleophilic substitutions, alkylations, and acylations. This reactivity makes it an excellent intermediate for the synthesis of more complex organic molecules, such as pharmaceuticals and agrochemicals. Researchers often investigate its role as a ligand in coordination chemistry or its potential biological activities, such as inhibiting specific enzymes like NOS2 (iNOS). When you seek to purchase this intermediate, understanding these properties helps in selecting the right grade and manufacturer.

Solubility Profile
The solubility of 4-Methylpyridin-2-amine is another key property. It is commonly soluble in polar organic solvents like alcohols (ethanol, methanol), dimethyl sulfoxide (DMSO), ethyl acetate, and chloroform. While it has moderate solubility in water, its solubility tends to increase with temperature, a factor that can be leveraged in reaction design. Understanding its solubility is crucial for selecting appropriate reaction media and purification solvents when you buy and process this chemical.

Sourcing High-Quality Material
When sourcing 4-Methylpyridin-2-amine, it is essential to partner with a reputable supplier or manufacturer. Look for detailed product specifications, including purity (often specified as ≥98.0%), and ensure that the supplier can provide comprehensive safety data sheets (SDS) and certificates of analysis (CoA). Competitive prices are also important, but should not come at the expense of quality. Many Chinese manufacturers offer this intermediate at attractive price points, making them a preferred choice for bulk procurement.

Conclusion
4-Methylpyridin-2-amine is a compound of significant chemical interest due to its versatile properties and applications. Its well-defined physical and chemical characteristics, coupled with its reactivity, make it an invaluable intermediate for R&D chemists and formulation scientists. By understanding these properties and choosing a dependable supplier, you can effectively integrate 4-Methylpyridin-2-amine into your synthesis strategies.