In the realm of organic chemistry and pharmaceutical manufacturing, specific intermediates play pivotal roles in the creation of complex and vital molecules. 4-Chloro-6-ethyl-5-fluoropyrimidine (CAS: 137234-74-3) is one such compound, recognized primarily for its indispensable function as an intermediate in the synthesis of Voriconazole, a critical antifungal medication. Understanding its chemical properties is key for chemists and procurement specialists aiming to effectively utilize and source this important chemical building block.

Physical and Chemical Characteristics: 4-Chloro-6-ethyl-5-fluoropyrimidine is typically described as a clear to light yellow liquid. Its molecular formula is C6H6ClFN2, and it has a molecular weight of approximately 160.58 g/mol. Key physical properties reported include a boiling point around 211°C at standard atmospheric pressure and a flash point of approximately 81°C. Its density is around 1.286 g/cm³. These properties are essential for safe handling, storage, and processing within chemical synthesis operations. The presence of the chlorine atom on the pyrimidine ring suggests potential for nucleophilic substitution reactions, a characteristic exploited in its synthetic applications.

Key Application: Voriconazole Synthesis: The primary and most significant application of 4-Chloro-6-ethyl-5-fluoropyrimidine is its role as a crucial intermediate in the synthesis of Voriconazole. Voriconazole is a potent, broad-spectrum triazole antifungal agent widely used to treat severe invasive fungal infections, including those caused by resistant Candida species and Aspergillus. The specific structural features of 4-Chloro-6-ethyl-5-fluoropyrimidine make it an ideal precursor for building the complex molecular architecture of Voriconazole. Pharmaceutical companies looking to manufacture this vital drug must secure a reliable supply of this high-purity intermediate.

Sourcing and Quality Considerations: When procuring 4-Chloro-6-ethyl-5-fluoropyrimidine, buyers prioritize high purity, often specified as ≥98.0% by HPLC. Manufacturers must ensure consistent quality and supply chain reliability. Sourcing from established chemical suppliers and manufacturers, particularly those with a strong presence in China, can offer competitive pricing and access to large quantities. It is advisable to request a Certificate of Analysis (CoA) with each batch to confirm specifications and purity. Furthermore, understanding the typical storage conditions (e.g., cool, ventilated place) is important for maintaining product integrity.

Beyond Voriconazole: Potential Uses: While its role in Voriconazole synthesis is dominant, the unique structure of 4-Chloro-6-ethyl-5-fluoropyrimidine suggests potential utility as a building block in other areas of organic synthesis, particularly in the development of novel bioactive compounds or specialty chemicals. Its fluorinated pyrimidine core offers opportunities for creating diverse chemical libraries for drug discovery or materials science research. Researchers and chemical developers seeking specialized fluorinated pyrimidines for novel applications can explore this compound as a versatile starting material.

In summary, 4-Chloro-6-ethyl-5-fluoropyrimidine is a chemically significant intermediate whose properties are tailored for its critical role in Voriconazole production. Its availability from reliable manufacturers ensures that this vital antifungal medication can be synthesized efficiently and effectively, contributing to global healthcare.