Rifamycin O (CAS 14487-05-9) is a compound of significant interest within the pharmaceutical industry, primarily due to its role as a precursor in the synthesis of certain antibiotics. Understanding its chemical properties is fundamental to appreciating its applications and the stringent handling requirements that accompany it.

As a member of the rifamycin family, Rifamycin O possesses a complex macrocyclic structure characteristic of this antibiotic class. Typically appearing as a yellow to dark yellow solid, its physical form is a key identifier. The melting point, often cited around 171°C with decomposition, indicates a thermal sensitivity that necessitates careful storage conditions, typically at -20°C under an inert atmosphere. This ensures the compound's stability and prevents degradation, which is crucial for maintaining its efficacy as a pharmaceutical intermediate.

The molecular formula C39H47NO14 and a molecular weight of approximately 753.79 g/mol highlight its intricate organic nature. Its solubility is generally limited, being slightly soluble in chloroform and methanol, often requiring specific solvents or heated conditions for dissolution. This characteristic influences how it is processed in synthesis reactions and formulation development.

Key Applications: The Heart of Antibiotic Synthesis

The primary and most critical application of Rifamycin O is its function as a key intermediate in the synthesis of Rifaximin. Rifaximin, a potent antibiotic, relies on Rifamycin O for its structural foundation. The transformation of Rifamycin O into Rifaximin involves specific chemical reactions that build upon its existing molecular framework. Consequently, the purity and quality of the Rifamycin O used directly impact the yield and purity of the final Rifaximin API.

Furthermore, Rifamycin O serves as an important reference standard, particularly in quality control processes for Rifaximin. Pharmaceutical manufacturers utilize high-purity Rifamycin O to identify and quantify any related impurities in their finished drug products. This meticulous quality assurance is vital for meeting regulatory standards and ensuring patient safety.

Beyond Rifaximin, Rifamycin O's structural similarity to other biologically active rifamycins makes it a valuable compound for ongoing pharmaceutical research and development. Scientists can use it to explore new antibiotic derivatives, investigate mechanisms of action, or develop novel therapeutic strategies against bacterial infections.

Safety Considerations for Chemical Intermediates

As with many specialized chemical compounds, Rifamycin O requires careful handling. Safety data sheets often indicate hazards such as potential organ damage and environmental toxicity. This underscores the importance of adhering to strict safety protocols during its storage, handling, and disposal. Users must employ appropriate personal protective equipment and follow recommended procedures to mitigate risks.

For procurement, identifying a reliable manufacturer and supplier like NINGBO INNO PHARMCHEM CO., LTD. is paramount. We ensure that our Rifamycin O (CAS 14487-05-9) is produced under controlled conditions, meeting the purity and quality specifications demanded by the pharmaceutical industry. Our commitment to providing comprehensive product information, competitive pricing, and reliable delivery supports researchers and manufacturers in their critical work. By understanding and valuing the chemical properties and applications of Rifamycin O, we contribute to the advancement of antibiotic therapies worldwide.