For professionals working with specialty chemicals, a thorough understanding of product properties and safe handling practices is paramount. 5-Bromo-1,2,3-trifluorobenzene (CAS: 138526-69-9) is a valuable intermediate in organic synthesis, and knowing its characteristics ensures efficient and safe utilization. As a leading manufacturer and supplier, we provide essential information to help researchers and safety officers handle this compound with confidence.

Chemically, 5-Bromo-1,2,3-trifluorobenzene is a fluorinated aromatic compound with the molecular formula C6H2BrF3 and a molecular weight of approximately 210.98. Its key physical properties include its appearance as a colorless clear liquid, a boiling point of 47-49 °C, and a melting point below -20 °C. These characteristics make it easy to handle and measure in various laboratory settings. The density is approximately 1.767 g/cm³, and it has a flash point of 113°C, indicating a moderate flammability risk that requires appropriate precautions.

The reactivity of 5-Bromo-1,2,3-trifluorobenzene is primarily driven by the bromine atom and the electron-withdrawing trifluorinated phenyl ring. The bromine atom serves as an excellent leaving group, readily participating in various palladium-catalyzed cross-coupling reactions, such as Suzuki, Sonogashira, and Buchwald-Hartwig amination. These reactions are fundamental for building more complex molecular structures, making this compound a cornerstone for synthesizing advanced pharmaceuticals, agrochemicals, and materials for electronic applications. When you buy this intermediate, these reaction pathways are often the primary reason for its selection.

Safe handling of 5-Bromo-1,2,3-trifluorobenzene is crucial. As a chemical intermediate, it should be handled in a well-ventilated area, preferably under a fume hood, to avoid inhalation of vapors. Personal protective equipment (PPE), including chemical-resistant gloves, safety goggles, and a lab coat, should always be worn. It is essential to avoid contact with skin and eyes. Referencing the Safety Data Sheet (SDS) provided by the supplier is the most reliable way to obtain comprehensive safety information.

Storage recommendations for 5-Bromo-1,2,3-trifluorobenzene typically include keeping the container tightly sealed in a cool, dry, and well-ventilated warehouse. It should be stored separately from incompatible materials, such as strong oxidizing agents, to prevent hazardous reactions. Proper storage ensures the compound's stability and maintains its high purity, which is critical for its subsequent use. Our commitment as a manufacturer extends to providing products that are stable and well-packaged for safe transport and storage.

In conclusion, understanding the chemical properties and safe handling procedures for 5-Bromo-1,2,3-trifluorobenzene is vital for its effective and secure use in chemical synthesis. We encourage all users to consult their SDS and to purchase this essential intermediate from a trusted manufacturer like us, ensuring both product quality and safety. If you require this compound for your research or production, please do not hesitate to contact our team to inquire about pricing and availability.