Understanding the fundamental chemical and physical properties of intermediates is crucial for any chemist or procurement specialist involved in chemical synthesis. 2,3-Dibromo-4-methylpyridine, a member of the pyridine family, is one such compound that offers significant utility across various industrial applications. This article will explore its key properties, discuss its typical synthesis methods, and highlight why sourcing from reliable manufacturers, particularly those in China, is advantageous for ensuring quality and availability.

Key Chemical and Physical Characteristics

2,3-Dibromo-4-methylpyridine (CAS: 871483-22-6) is typically characterized by its appearance as a light-yellow to yellow crystalline powder. This physical form is often indicative of its purity and handling characteristics. With a molecular formula of C6H5Br2N and a molecular weight of approximately 250.92 g/mol, its structure features a pyridine ring substituted with two bromine atoms at the 2 and 3 positions, and a methyl group at the 4 position. These bromine atoms serve as highly reactive sites, making the compound a valuable electrophile in various organic transformations. The density is reported around 1.9 g/cm³, and a boiling point of approximately 270.4 °C at 760 mmHg indicates a relatively stable, high-boiling compound. A typical assay for commercially available material is ≥98.0%, with a moisture content limit of ≤0.5%. These specifications are critical for chemists who need reliable reactants for their synthesis projects.

Common Synthesis Routes

The synthesis of 2,3-Dibromo-4-methylpyridine commonly involves electrophilic aromatic substitution reactions. One prevalent method includes the bromination of 4-methylpyridine (also known as 4-picoline) under specific reaction conditions designed to favor dibromination at the desired positions. This often involves using brominating agents such as elemental bromine, potentially in the presence of a catalyst or specific solvent systems. Another approach might involve starting with a pre-functionalized pyridine ring and introducing the bromine atoms or methyl group sequentially. While specific proprietary methods may vary among manufacturers, the general principle involves controlled halogenation of a pyridine derivative. For companies looking to buy 2,3-Dibromo-4-methylpyridine, understanding these synthesis routes can provide insights into potential impurities and the quality control measures employed by the manufacturer.

Sourcing from Reputable Manufacturers in China

China has emerged as a global hub for chemical manufacturing, offering a vast array of intermediates like 2,3-Dibromo-4-methylpyridine. For businesses and research institutions seeking to purchase this compound, partnering with established Chinese manufacturers provides several benefits. These include competitive pricing due to economies of scale, a wide range of purity options, and the ability to scale production for larger orders. When evaluating a supplier, it is essential to look for companies with robust quality management systems, transparent documentation (such as CoAs and SDS), and a track record of reliable delivery. Engaging directly with a manufacturer allows for clearer communication and can often lead to more favorable terms. If your R&D or production requires this key pyridine intermediate, explore the offerings from trusted Chinese suppliers to ensure you receive a high-quality product that meets your exact specifications.

In summary, 2,3-Dibromo-4-methylpyridine is a compound with well-defined chemical and physical properties that make it an indispensable tool in organic synthesis. Its availability from reliable manufacturers, particularly in China, ensures that researchers and industries can access this vital intermediate for their critical applications. If you are in the market to buy this compound, focusing on purity and supplier reliability will pave the way for successful chemical endeavors.