For chemists and material scientists, a thorough understanding of a chemical's properties and synthesis pathways is fundamental to its effective utilization. 2,5-Difluoro-4-nitrobenzoic acid (CAS: 116465-48-6) is a fascinating molecule with specific chemical characteristics that make it valuable in various industrial applications, primarily as an intermediate in organic synthesis.

The molecular structure of 2,5-Difluoro-4-nitrobenzoic acid features a benzene ring substituted with two fluorine atoms at positions 2 and 5, a nitro group at position 4, and a carboxylic acid group. Its molecular formula is C7H3F2NO4, with a molecular weight of approximately 203.10 g/mol. Key physical properties include a melting point typically in the range of 147-148°C and an appearance as a light yellow crystalline powder. The presence of fluorine atoms significantly impacts the electron distribution within the aromatic ring, influencing its reactivity and the acidity of the carboxylic acid group. The nitro group also acts as an electron-withdrawing group, further activating the ring for certain nucleophilic aromatic substitution reactions or serving as a precursor to an amino group upon reduction.

Regarding its synthesis, while specific proprietary methods exist, common routes often involve the functionalization of suitably substituted benzene derivatives. For instance, one approach might start with a difluorinated toluene derivative, followed by nitration and subsequent oxidation of the methyl group to a carboxylic acid. Another potential pathway could involve the nitration of a difluorobenzoic acid precursor. Manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. optimize these synthesis routes to achieve high yields and purity levels, typically ≥98.0%.

When considering the purchase of 2,5-Difluoro-4-nitrobenzoic acid, understanding these chemical properties and synthesis considerations helps in evaluating its suitability for specific applications. Whether used as a building block for complex pharmaceuticals, agrochemicals, or advanced materials, its unique structural features are key to its utility. Ensuring high purity through reliable suppliers is crucial for reproducible results in any chemical synthesis endeavor.