In the realm of chemical research and development, understanding the properties and synthesis of key intermediates is paramount. 2-Benzylpropionic Acid (CAS 1009-67-2), also known as alpha-Methylhydrocinnamic acid, is a significant compound frequently employed as a pharmaceutical intermediate. This article explores its chemical characteristics, common synthesis pathways, and the analytical techniques essential for its characterization, providing valuable insights for researchers.

Chemical Profile of 2-Benzylpropionic Acid

2-Benzylpropionic Acid is an organic carboxylic acid with the molecular formula C₁₀H₁₂O₂ and a molecular weight of approximately 164.20 g/mol. It typically appears as a white crystalline powder, a testament to its high purity, often exceeding 99.00%. The compound features a phenyl ring attached to a propanoic acid backbone, with a benzyl group also connected to the second carbon atom of the propanoic acid chain. This structure lends itself to various chemical transformations, making it a versatile intermediate in organic synthesis.

Synthesis Pathways for 2-Benzylpropionic Acid

The synthesis of 2-Benzylpropionic Acid can be achieved through several organic chemistry routes. One common approach involves the synthesis of benzyl chloride intermediates. For example, reactions can proceed via the condensation of benzyl chloride with derivatives of phenylpropanoic acid under basic conditions. Optimization of yield and purity often involves carefully controlled reaction conditions, including stoichiometry, temperature, and solvent choice. Refluxing in ethanol-water mixtures is frequently used for purification via recrystallization, ensuring the desired white crystalline powder is obtained.

Researchers seeking to buy 2-benzylpropionic acid for R&D purposes will find that many manufacturers offer it as a standard fine chemical reagent. The availability of detailed synthesis information from a 2-benzylpropionic acid manufacturer can be invaluable for understanding potential impurities and optimizing subsequent reactions.

Analytical Methods for Characterization and Purity Assessment

Confirming the identity and purity of 2-Benzylpropionic Acid is critical for its application in pharmaceutical synthesis. Researchers commonly employ a suite of analytical techniques:

  • Nuclear Magnetic Resonance (NMR) Spectroscopy: Both ¹H NMR and ¹³C NMR are indispensable. The ¹H NMR spectrum should reveal characteristic signals for the aromatic protons (typically δ 7.2–7.4 ppm) and distinct aliphatic proton signals, including a triplet for the α-proton adjacent to the carboxylic acid group (δ 2.8–3.1 ppm).
  • Infrared (IR) Spectroscopy: This technique confirms the presence of key functional groups. A strong absorption band around 1700 cm⁻¹ indicates the carboxylic acid C=O stretch, a signature for this compound.
  • High-Performance Liquid Chromatography (HPLC): HPLC, often using a C18 column with an acetonitrile/water mobile phase, is the standard for purity assessment. A purity of ≥95% is generally considered acceptable for in vitro studies, while ≥99% is preferred for more rigorous applications like X-ray crystallography.
  • Mass Spectrometry (MS): MS provides the molecular weight and fragmentation patterns, aiding in structural confirmation.

By leveraging these analytical methods, researchers can confidently use 2-Benzylpropionic Acid in their experiments. When you purchase alpha-methylhydrocinnamic acid, ensure that the supplier provides access to comprehensive analytical data to support your research endeavors.

Conclusion: Reliable Intermediate for Innovation

2-Benzylpropionic Acid (CAS 1009-67-2) remains a valuable compound for chemical researchers. Its well-defined chemical properties and accessible synthesis pathways, coupled with robust analytical methods for characterization, make it a reliable intermediate for advancing pharmaceutical and organic synthesis projects. For those needing to buy 2-benzylpropionic acid, partnering with a reputable China manufacturer ensures quality and consistency.