4-Bromo-2,6-difluoroaniline, identified by its CAS number 67567-26-4, is a chemical compound of considerable interest due to its distinctive structural features and reactivity. As a fluorinated aromatic amine, it possesses a unique blend of properties that make it a valuable intermediate in various chemical synthesis processes, particularly in the pharmaceutical, agrochemical, and material science sectors. Understanding its chemical properties and synthesis routes is crucial for researchers and manufacturers alike.

Chemically, 4-Bromo-2,6-difluoroaniline is an aniline derivative substituted with a bromine atom at the para position and two fluorine atoms at the ortho positions relative to the amino group. This specific arrangement of substituents imparts distinct electronic and steric effects. The electronegativity of the fluorine atoms influences the electron density of the aromatic ring, affecting its reactivity in electrophilic aromatic substitution reactions. The presence of the bromine atom provides a handle for various coupling reactions, such as Suzuki, Stille, or Heck couplings, which are instrumental in building larger, more complex molecules.

The amino group (-NH2) is nucleophilic and can undergo a range of reactions, including acylation, alkylation, and diazotization. Diazotization, in particular, is a key reaction pathway that converts the amino group into a diazonium salt, which is a highly versatile intermediate for introducing various other functional groups onto the aromatic ring or for forming azo compounds.

The synthesis of 4-Bromo-2,6-difluoroaniline often involves the electrophilic bromination of 2,6-difluoroaniline. A common method, as suggested in literature, involves reacting 2,6-difluoroaniline with bromine in a suitable solvent, often acetic acid. The reaction conditions, such as temperature and reaction time, are carefully controlled to optimize yield and minimize the formation of by-products. Post-reaction work-up typically involves neutralization and extraction with organic solvents, followed by purification techniques like crystallization or chromatography to achieve the desired purity.

For businesses looking to procure 4-Bromo-2,6-difluoroaniline, understanding its chemical properties is key to identifying its potential applications and optimal handling procedures. High purity, often u226599%, is critical for most synthetic applications. NINGBO INNO PHARMCHEM CO.,LTD., as a dedicated manufacturer and supplier, ensures that our 4-Bromo-2,6-difluoroaniline meets these stringent purity requirements. We offer this vital chemical intermediate, supporting your synthesis needs with a reliable supply chain and competitive pricing.

When you need to buy 4-Bromo-2,6-difluoroaniline for your research or production, choosing a manufacturer with expertise in fluorinated compounds and aromatic amines is advantageous. Our commitment to quality and efficient production processes ensures that you receive a product that adheres to the highest standards, enabling successful outcomes in your chemical synthesis projects.

In summary, the chemical structure and reactivity of 4-Bromo-2,6-difluoroaniline make it a cornerstone intermediate for many advanced chemical syntheses. By understanding its properties and sourcing from reliable manufacturers like NINGBO INNO PHARMCHEM CO.,LTD., you can confidently integrate this compound into your workflows.