For chemists and formulators in the pharmaceutical industry, a deep understanding of the chemical properties and synthesis of key intermediates like 6-Aminouracil (CAS 873-83-6) is fundamental. This knowledge not only aids in optimizing existing processes but also in exploring new applications and synthesis routes. As a prominent supplier of pharmaceutical intermediates, we aim to shed light on these critical aspects.

Chemical and Physical Properties of 6-Aminouracil

6-Aminouracil, also known as 4-amino-2,6-dihydroxypyrimidine, presents as a light yellow crystalline powder. Its molecular formula is C4H5N3O2, with a molecular weight of approximately 127.10 g/mol. A key characteristic is its high melting point, typically reported as ≥360°C, indicating thermal stability under many processing conditions. Its solubility profile shows it is slightly soluble in water and methanol, but may require heating for dissolution in DMSO. This solubility behavior is crucial when planning purification steps or reaction media.

The compound’s structure features a pyrimidine ring with an amino group and two hydroxyl groups, which are tautomeric with keto groups. This molecular architecture is what makes it a versatile building block for more complex pharmaceutical molecules.

Synthesis of 6-Aminouracil

The synthesis of 6-Aminouracil typically involves condensation reactions. A common method described in chemical literature uses ethyl cyanoacetate reacting with urea, methylurea, or methylthiourea in the presence of a strong base, such as sodium ethoxide, in anhydrous ethanol. The reaction is usually refluxed for several hours, followed by acidification to precipitate the product. Subsequent purification steps, which might involve dissolving in aqueous ammonia and re-precipitation with an acid, are often employed to achieve the high purity required for pharmaceutical use. The yield and purity can vary based on reaction conditions and purification techniques.

Importance in Pharmaceutical Manufacturing

The synthesis of drugs like caffeine, theophylline, and SDM relies on the availability of high-purity 6-Aminouracil. Manufacturers who can reliably supply this intermediate, adhering to strict quality control and precise specifications (like 99% purity), are invaluable partners. Understanding the synthesis process allows us, as manufacturers, to control critical parameters that influence the final product’s quality and consistency. For procurement managers and R&D scientists seeking to buy 6-Aminouracil, partnering with experienced suppliers who understand these nuances is essential.

By maintaining a robust manufacturing process and stringent quality checks, we ensure our 6-Aminouracil (CAS 873-83-6) meets the demanding requirements of the pharmaceutical industry, supporting your critical synthesis needs from a trusted supplier in China.