The efficacy of pharmaceutical products relies heavily on the quality and purity of their constituent intermediates. 6-Chloropyridazin-3-amine, a significant pyridazine derivative, plays a pivotal role in this regard. This article provides an in-depth look at its chemical properties, synthesis, and the critical aspects that make it a sought-after compound in the pharmaceutical sector.

Chemical Structure and Properties: The Foundation of Reactivity

6-Chloropyridazin-3-amine, with the CAS number 5469-69-2, possesses a distinct chemical structure featuring a pyridazine ring substituted with a chlorine atom and an amino group. This arrangement imbues the molecule with specific reactivity, making it a versatile building block in organic synthesis. Its physical form is typically a light brown to brown solid, with a melting point of 210°C, indicating good thermal stability. The predicted boiling point is 363.2±22.0 °C, and its density is approximately 1.437±0.06 g/cm³. The compound's solubility in solvents like DMSO and methanol (when heated) is moderate, which is a crucial consideration for reaction conditions and purification processes. The pKa of 4.06±0.10 suggests it behaves as a weak base.

Synthesis of 6-Chloropyridazin-3-amine: A Look at Production Methods

The synthesis of 6-Chloropyridazin-3-amine often involves the reaction of 3,6-dichloropyridazine with ammonia in a methanol solution. A typical procedure involves slowly adding 3,6-dichloropyridazine to a 2.0 M ammonia-methanol solution. The mixture is then heated under specific conditions, such as 130°C for 96 hours, followed by cooling. Post-reaction processing usually includes the addition of water, extraction with ethyl acetate, washing with saturated aqueous sodium chloride, drying over anhydrous sodium sulfate, and concentration under reduced pressure. Purification through column chromatography yields the target compound, often with a reported yield of around 61%, resulting in a white solid. The verification of its structure is typically done through NMR spectroscopy, confirming the presence and arrangement of its key chemical components. For manufacturers, optimizing these synthesis steps is key to achieving high yields and purity, essential for meeting the stringent demands when looking to purchase pharmaceutical intermediates.

Quality Assurance and Sourcing from China

NINGBO INNO PHARMCHEM CO.,LTD. understands the critical need for quality in pharmaceutical intermediates. Our commitment to producing 6-Chloropyridazin-3-amine with a purity of ≥99% and a moisture content of ≤0.02% ensures that our clients receive a product that meets global pharmaceutical standards. Leveraging China's extensive chemical manufacturing capabilities, we are able to provide this vital intermediate reliably and cost-effectively. By focusing on precise synthesis and rigorous quality control, we aim to be a premier supplier for companies seeking to buy 6-Chloropyridazin-3-amine online for their manufacturing processes.

Conclusion

The detailed understanding of 6-Chloropyridazin-3-amine's chemical properties and synthesis pathways is fundamental to its successful application in pharmaceutical manufacturing. NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing high-quality, consistently produced 6-Chloropyridazin-3-amine, supporting the development and production of essential medicines worldwide.