Diethyl (tosyloxy)methylphosphonate, identified by CAS number 31618-90-3, is a significant chemical intermediate with a molecular formula of C12H19O6PS and a molecular weight of 322.31. It is typically described as a light yellow or colorless transparent oily liquid, a physical characteristic that dictates its handling and storage protocols. Understanding its chemical properties is fundamental for researchers and manufacturers looking to utilize it effectively in synthesis.

The compound's chemical structure features a diethyl phosphonate group linked to a methyl group, which is further esterified with p-toluenesulfonic acid (tosyl group). This arrangement imparts specific reactivity, making it a valuable reagent in organic synthesis. The tosylate group acts as an excellent leaving group, facilitating nucleophilic substitution reactions. This reactivity is central to its application as a pharmaceutical intermediate, particularly in the introduction of phosphonate functionalities into drug molecules.

While detailed proprietary synthesis routes are often guarded by manufacturers, general methods for preparing Diethyl (tosyloxy)methylphosphonate involve the reaction of diethyl hydroxymethylphosphonate with p-toluenesulfonyl chloride. This reaction typically occurs in the presence of a base to neutralize the generated hydrochloric acid and promote the tosylation. Optimization of reaction conditions, such as temperature, solvent, and reagent stoichiometry, is critical for achieving high purity and yield, ensuring the product meets stringent pharmaceutical standards. For companies seeking to buy this intermediate, engaging with suppliers who possess robust synthesis capabilities is paramount.

The applications of Diethyl (tosyloxy)methylphosphonate are predominantly within the pharmaceutical industry, serving as a crucial intermediate for antiviral drugs like Tenofovir. Its role in creating nucleoside analogues is well-established. Beyond this primary use, its versatile chemical structure suggests potential applications in other areas of fine chemical synthesis. Researchers actively explore new uses for this compound, contributing to the broader field of chemical innovation.

As a chemical manufacturer, our focus is on consistently delivering Diethyl (tosyloxy)methylphosphonate that adheres to strict quality control measures. We understand that the success of our clients' drug development programs hinges on the quality of the intermediates they use. Therefore, we invest in advanced synthesis techniques and rigorous analytical testing to guarantee the purity and performance of our products, making us a reliable supplier for the global pharmaceutical market.