For chemists and product developers, a deep understanding of a chemical intermediate's properties and synthesis pathways is crucial for successful application. N-(4-Cyanophenyl)guanidine (CAS 5637-42-3) is a valuable compound known for its role in various synthesis projects, particularly within the pharmaceutical and agrochemical industries. Examining its chemical properties and common production methods provides insight into its utility and sourcing considerations.

N-(4-Cyanophenyl)guanidine is typically identified by its white crystalline appearance. Its physical state as a solid facilitates handling and storage. Crucially, it exhibits good solubility in common polar organic solvents such as DMSO and methanol, which is advantageous for its use in reaction mixtures. The compound's melting point is generally reported in the range of 205-215 °C, indicating a relatively stable structure under typical laboratory conditions. These properties, combined with its high purity (often ≥98% HPLC), make it a preferred intermediate for demanding chemical synthesis.

The synthesis of N-(4-Cyanophenyl)guanidine commonly involves the reaction between p-aminobenzonitrile and cyanamide. One established method involves reacting p-aminobenzonitrile with cyanamide in the presence of an acid catalyst. For example, a procedure might involve refluxing p-aminobenzonitrile with nitric acid and an ammoniacal nitrile solution, followed by cooling and precipitation with methyl tert-butyl ether. Subsequent purification steps, such as dissolving in water and treating with sodium hydroxide, then filtering and drying, yield the final N-(4-Cyanophenyl)guanidine product. Manufacturers often optimize these processes for yield and purity.

When seeking to buy N-(4-Cyanophenyl)guanidine, understanding these synthesis details can help in evaluating potential suppliers. A manufacturer that clearly outlines its synthetic routes and quality control measures is more likely to provide a reliable product. For procurement managers, inquiring about the manufacturing process and purity verification methods is a standard practice to ensure the compound meets project specifications.

The chemical properties and synthesis of N-(4-Cyanophenyl)guanidine underscore its importance as a versatile intermediate. Its solubility in organic solvents, crystalline form, and high purity make it a prime candidate for integration into complex synthetic routes. Whether you are a researcher or a production manager, understanding these aspects will guide your sourcing decisions and ensure you acquire this vital chemical from a trusted manufacturer at a competitive price.