The field of organic chemistry, particularly within pharmaceutical development, relies on a vast array of specialized compounds. Among these, derivatives featuring the 1,1-dimethylethyl ester (often referred to as tert-butyl ester or Boc group) functionality are particularly prevalent due to their utility in protecting amine groups and their specific cleavage conditions. A prime example is 4-[2-(Aminooxy)ethoxy]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester (CAS: 1452466-34-0), a vital intermediate in the synthesis of Avibactam.

For chemists and process engineers, understanding the physical and chemical properties of such intermediates is fundamental. This compound, with its defined molecular formula (C12H24N2O4) and molecular weight (260.330), exhibits specific characteristics like a density of 1.1±0.1 g/cm³ and a high boiling point (377.3±37.0 °C at 760 mmHg). These properties are crucial for designing efficient reaction conditions and purification protocols. The presence of the Boc-protected piperidine ring and the aminooxyethoxy side chain makes it a versatile building block for complex molecular architectures.

When looking to buy this or similar 1,1-dimethylethyl ester derivatives, it is imperative to source them from reputable chemical suppliers. Identifying a reliable manufacturer, particularly one operating in China with expertise in fine chemical synthesis, can provide access to high-purity materials (assay ≥98.0%) at competitive price points. These suppliers typically offer bulk supply options, such as 25 kg/drum packaging, catering to the needs of commercial pharmaceutical production.

The primary application for 4-[2-(Aminooxy)ethoxy]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester lies in its role as an intermediate for Avibactam. However, the underlying structural motifs—a functionalized piperidine ring and a protected aminooxy group—suggest potential applications in other areas of medicinal chemistry and drug discovery. Researchers seeking unique building blocks for novel compound libraries might find this intermediate of interest.

Establishing a relationship with a skilled chemical company that specializes in the synthesis and supply of these complex organic molecules is key to successful pharmaceutical development. Ensuring consistent quality and timely delivery from your chosen supplier is a critical factor in managing project timelines and overall production efficiency.