In the realm of fine chemicals and organic synthesis, specific molecular structures serve as critical linchpins for developing advanced materials and pharmaceutical compounds. 1-Bromo-4-chloro-2-fluorobenzene, identified by its CAS number 1996-29-8, is one such compound, offering a unique combination of halogen substituents that make it highly valuable for a variety of chemical transformations. This article provides an in-depth look at its properties, applications, and sourcing considerations for industry professionals.

The chemical name, 1-Bromo-4-chloro-2-fluorobenzene, precisely describes its structure: a benzene ring substituted with a bromine atom at position 1, a chlorine atom at position 4, and a fluorine atom at position 2. This arrangement of halogens significantly influences its reactivity. The compound is typically described as a light yellow liquid with a purity assay of ≥99.0%, a boiling point of approximately 91-92 °C at 20 mmHg, and a density of around 1.678 g/mL at 25 °C. These physical and chemical properties are crucial for its handling, storage, and application in synthetic processes.

The primary utility of 1-Bromo-4-chloro-2-fluorobenzene lies in its role as an intermediate in organic synthesis. It is particularly noted for its application in the preparation of pharmaceutical intermediates, including precursors for compounds that exhibit antidepressant effects. Its structure is well-suited for Suzuki couplings, enabling the formation of biphenyl derivatives which are then used in the synthesis of complex pharmaceutical agents. Researchers looking to buy this compound often seek out a reliable supplier who can guarantee these precise specifications.

For manufacturers and procurement specialists, sourcing such a specialized chemical requires careful consideration of several factors. The purity of the compound is paramount, as even minor impurities can derail sensitive synthesis pathways. Therefore, partnering with a trusted manufacturer that implements rigorous quality control is essential. Additionally, competitive pricing and a stable supply chain are vital for maintaining operational efficiency and cost-effectiveness.

The synthesis of 1-Bromo-4-chloro-2-fluorobenzene typically involves multi-step organic chemistry processes, starting from readily available precursors. Companies that excel in this area often possess specialized expertise in halogenation and aromatic chemistry. For those in need of this intermediate, exploring options from established chemical suppliers, particularly those based in China with a strong presence in the global fine chemical market, can provide access to high-quality products at favorable prices.

In conclusion, 1-Bromo-4-chloro-2-fluorobenzene (CAS 1996-29-8) is a critical component in modern organic synthesis, particularly within the pharmaceutical industry. Its unique chemical properties and established applications make it a sought-after intermediate. By focusing on purity, reliability, and cost-effectiveness when choosing a manufacturer or supplier, researchers and businesses can effectively leverage this versatile building block for their advanced synthesis needs.