2,4,6-Triaminopyrimidine (CAS 1004-38-2) is a compound that holds significant importance within the chemical and pharmaceutical industries. Its unique molecular structure, featuring a pyrimidine ring with three amine substituents, dictates its reactivity and utility as a versatile intermediate. Understanding its physico-chemical properties is key to appreciating its broad range of applications, from drug synthesis to other specialized chemical processes.

Understanding the Chemical Profile

The chemical name for this compound is Pyrimidine-2,4,6-triamine. Its molecular formula is C4H7N5, with a molecular weight of approximately 125.13 g/mol. Typically, it appears as an off-white to beige powder. Key physical properties include a melting point in the range of 246-252°C, indicating its solid state at room temperature. While it exhibits solubility in water (approximately 36.5 g/L at 20°C), it is less soluble in organic solvents like alcohol and ether. The aqueous solution of 2,4,6-Triaminopyrimidine is known to be alkaline.

These properties make it suitable for reactions where a nucleophilic amine moiety is required or where the pyrimidine scaffold is essential for molecular design. The presence of multiple amine groups allows for various derivatization pathways, enabling chemists to build complex molecular architectures.

Applications: A Cornerstone in Synthesis

The primary application of 2,4,6-Triaminopyrimidine lies in its role as a pharmaceutical intermediate. It is an indispensable building block for the synthesis of several critical drugs, most notably:

  • Antineoplastic Drugs: Used in treatments aimed at preventing or inhibiting the growth of tumors.
  • Anticancer Drugs: Crucial for developing therapies that target and eliminate cancer cells.
  • Amphenypteridine and Methotrexate: Specifically used in the established synthesis routes for these well-known pharmaceuticals.

Beyond these direct pharmaceutical applications, its reactive nature makes it a valuable compound for general organic synthesis. Researchers may explore its use in creating novel heterocyclic compounds, potential agrochemicals, or even as a component in the development of specialty materials. For those looking to buy 2,4,6-Triaminopyrimidine, understanding these applications helps in appreciating its value and demand in the market. Engaging with a reputable supplier or manufacturer ensures access to high-quality material for these diverse synthetic needs.

Sourcing Considerations for Quality and Reliability

When procuring 2,4,6-Triaminopyrimidine, especially for pharmaceutical applications, it is vital to work with experienced manufacturers and suppliers who can guarantee stringent quality control and consistent purity. Factors such as assay percentage (typically ≥98.00%) and proper storage conditions (cool, well-ventilated area, tightly closed container) are essential for maintaining product integrity. For companies in need of this intermediate, exploring options from reliable suppliers in China can offer a combination of quality and competitive pricing.

In summary, 2,4,6-Triaminopyrimidine is a testament to the importance of foundational chemical intermediates in driving innovation across various scientific disciplines, particularly in the development of life-saving pharmaceuticals.