2,4-Difluorobenzonitrile, identified by its CAS number 3939-09-1, is a specialty chemical compound that plays a pivotal role in modern organic synthesis, particularly within the pharmaceutical and agrochemical sectors. Its unique molecular structure, featuring a benzonitrile core substituted with two fluorine atoms at the ortho and para positions, confers specific reactivity and properties that make it an indispensable building block for chemists. Understanding these properties is key for researchers and manufacturers looking to leverage its potential.

From a chemical perspective, the presence of the electron-withdrawing nitrile group and the highly electronegative fluorine atoms significantly influences the electron distribution within the benzene ring. This electron deficiency makes the ring susceptible to nucleophilic aromatic substitution, particularly at the positions activated by the fluorine atoms. The fluorine at the 4-position (para to the nitrile) is generally more reactive due to a combination of electronic and steric factors, allowing for selective functionalization. This controlled reactivity is a primary reason why 2,4-difluorobenzonitrile is a preferred starting material for synthesizing more complex fluorinated compounds. Its molecular weight is approximately 139.10 g/mol, and it typically presents as a white to off-white crystalline powder with a melting point in the range of 47-49 °C.

The applications of 2,4-difluorobenzonitrile are diverse and impactful. In pharmaceutical development, it serves as a crucial intermediate for synthesizing a wide range of APIs. The incorporation of fluorine into drug molecules can often lead to improved pharmacological properties, such as enhanced lipophilicity, increased metabolic stability, and altered receptor binding affinity. Researchers frequently purchase 2,4-difluorobenzonitrile to construct novel drug candidates targeting various diseases. For those seeking to buy this intermediate, partnering with a reliable 2,4-difluorobenzonitrile manufacturer ensures consistent quality, which is paramount for pharmaceutical research and production.

Beyond pharmaceuticals, the agrochemical industry also benefits greatly from this versatile compound. 2,4-Difluorobenzonitrile is used in the synthesis of various pesticides, herbicides, and fungicides. The fluorinated nature of these agrochemicals can lead to increased potency, selective action, and improved environmental persistence profiles, contributing to more effective and sustainable crop protection. Companies involved in agricultural chemical manufacturing often procure this intermediate in significant quantities, making the 2,4-difluorobenzonitrile price and availability from suppliers a key factor in their strategic planning.

For chemists engaged in broader organic synthesis research, 2,4-difluorobenzonitrile offers a valuable tool for introducing specific functional groups and exploring new reaction pathways. Its availability from chemical reagent suppliers allows for its use in academic labs and industrial R&D settings for creating novel materials, catalysts, and complex organic structures. When considering the purchase of 2,4-difluorobenzonitrile, it is always advisable to look for suppliers that offer comprehensive technical data and support to ensure optimal utilization of this important chemical intermediate.