A deep understanding of a chemical intermediate's properties is crucial for its effective utilization in synthesis. 2-Bromo-4-methyl-5-nitropyridine (CAS: 23056-47-5) is a compound that exemplifies this, offering a unique set of physical and chemical characteristics that make it invaluable in various scientific and industrial applications, particularly in the pharmaceutical and agrochemical sectors.

Physical and Chemical Properties:

As a heterocyclic aromatic compound with the molecular formula C6H5BrN2O2, 2-Bromo-4-methyl-5-nitropyridine typically presents as a light yellow powder. Its melting point is generally reported in the range of 64-66°C, indicating a stable solid form under ambient conditions. While its boiling point is predicted to be around 294.2°C, this high temperature suggests that thermal stability is a consideration for high-temperature reactions. The compound's density is approximately 1.709 g/cm³, and it exhibits limited solubility in water but is soluble in organic solvents like methanol. These properties are essential for chemists to consider when designing reaction conditions, purification protocols, and storage strategies.

Reactivity and Synthetic Utility:

The chemical reactivity of 2-Bromo-4-methyl-5-nitropyridine is primarily dictated by its functional groups. The bromine atom is an excellent leaving group, making it susceptible to nucleophilic substitution reactions. This allows for the introduction of various nucleophiles, such as amines, alcohols, or thiols, to form new C-N, C-O, or C-S bonds, respectively. Furthermore, the bromine atom can participate in transition metal-catalyzed cross-coupling reactions, such as Suzuki, Stille, or Heck couplings, enabling the formation of complex carbon-carbon bonds. The nitro group can be readily reduced to an amino group, providing another handle for further chemical modification, such as acylation or diazotization.

Key Application Areas:

  • Pharmaceutical Synthesis: This intermediate is widely used in the pharmaceutical industry to synthesize drug candidates. Its structure is incorporated into molecules designed to treat a range of conditions, from cancer to infectious diseases. For instance, its role in synthesizing PLK1 inhibitors highlights its importance in oncology research.
  • Agrochemical Intermediates: In the agrochemical sector, 2-Bromo-4-methyl-5-nitropyridine is a key component in the synthesis of pesticides and herbicides, contributing to the development of more effective and targeted crop protection agents.
  • Research and Development: Organic chemists frequently utilize this compound as a versatile reagent for exploring new reaction methodologies and constructing complex molecular architectures.

Sourcing High-Quality 2-Bromo-4-methyl-5-nitropyridine:

To ensure the success of your synthetic projects, it is vital to buy 2-Bromo-4-methyl-5-nitropyridine from a reliable manufacturer. As a leading supplier based in China, we specialize in providing this intermediate with high purity (≥98.0% GC) and consistent quality. Our commitment to rigorous quality control and efficient production processes ensures that you receive a product that meets your exact specifications. We offer competitive pricing and dependable delivery, making us your ideal partner for all your chemical sourcing needs.

Understanding the properties and applications of 2-Bromo-4-methyl-5-nitropyridine empowers chemists to achieve breakthrough results. We invite you to explore our offerings and discover the advantage of partnering with a dedicated chemical supplier.