For professionals in the pharmaceutical and fine chemical industries, a thorough understanding of key intermediates is crucial for successful product development and manufacturing. 2-\(Diphenylmethyl\)thio\)acetamide (CAS 68524-30-1) is one such compound, widely recognized for its pivotal role in the synthesis of Modafinil, a prominent wakefulness-promoting agent. This article delves into its chemical characteristics, applications, and the importance of sourcing it from reliable manufacturers.

Chemical Identity and Properties

2-\(Diphenylmethyl\)thio\)acetamide, with the chemical name 2-\(Diphenylmethyl\)thio\)acetamide, is an organic compound characterized by its molecular formula C15H15NOS and a molecular weight of approximately 257.35 g/mol. It typically presents as a white to off-white solid, a crucial detail for visual quality assessment. Key physical and chemical properties that are vital for industrial handling and synthesis include:

  • Melting Point: Reported around 109-110 °C. This indicates a relatively stable solid form under ambient conditions.
  • Boiling Point: Approximately 427.7±33.0 °C at 760 mmHg (predicted), highlighting its thermal stability during chemical reactions.
  • Density: Around 1.183±0.06 g/cm³ (predicted), providing physical parameters for formulation and process design.
  • Assay: Typically ≥98.0%, signifying high purity essential for pharmaceutical applications.
  • Residue on Ignition: ≤0.5%, an important indicator of inorganic impurity content.

These properties are critical for procurement managers and formulators who need to ensure that the intermediate will perform reliably in their specific synthesis pathways.

The Central Role in Modafinil Synthesis

The primary significance of 2-\(Diphenylmethyl\)thio\)acetamide lies in its function as a key intermediate for Modafinil. This compound undergoes specific chemical transformations, often oxidation, to introduce the sulfinyl group characteristic of Modafinil. The reliability and purity of this precursor directly influence the efficiency and success rate of the Modafinil synthesis. Pharmaceutical companies worldwide rely on consistent access to high-quality 2-\(Diphenylmethyl\)thio\)acetamide for Modafinil production, making its procurement a strategic necessity.

Applications and Procurement Insights

Beyond its direct use in Modafinil synthesis, 2-\(Diphenylmethyl\)thio\)acetamide is also valuable in pharmaceutical research and development. Scientists may use it to explore related chemical structures or optimize synthesis routes. For businesses looking to buy 2-\(Diphenylmethyl\)thio\)acetamide, understanding its specifications and ensuring compliance with safety data sheets (SDS) is paramount. The compound is classified as harmful if swallowed and potentially toxic to aquatic life, necessitating proper handling and disposal procedures. When searching for a 2-\(Diphenylmethyl\)thio\)acetamide supplier, it's advisable to inquire about their adherence to safety and environmental standards.

By understanding the detailed chemical properties and applications of 2-\(Diphenylmethyl\)thio\)acetamide, R&D scientists and procurement specialists can make informed decisions, ensuring the selection of a product and supplier that meets the highest standards for pharmaceutical manufacturing.