In the realm of pharmaceutical synthesis, certain chemical compounds stand out for their critical role as intermediates. 2-Methyl-3-nitro-benzeneacetic acid, with CAS number 23876-15-5, is one such compound. Its utility as a precursor in the production of important pharmaceuticals makes it a subject of considerable interest for researchers and manufacturers alike. Understanding its chemical characteristics, synthesis methods, and specific applications is key to leveraging its potential effectively.

Chemical Profile and Properties

2-Methyl-3-nitro-benzeneacetic acid (Molecular Formula: C9H9NO4) is an organic compound distinguished by its nitro and phenylacetic acid moieties. It typically presents as a solid, often described as white to light yellow or light orange. Key physical properties include a melting point in the range of 132-136 °C and a density of approximately 1.346 g/cm³. The compound is soluble in methanol, indicating a degree of polarity. Its pKa of around 4.05 suggests it is a weak acid. The detailed structural information and chemical reactivity make it an ideal candidate for targeted synthetic pathways in the pharmaceutical industry. When searching for this chemical, using its CAS number, 23876-15-5, is the most precise way to identify it among the vast array of chemical compounds available from global suppliers.

Synthesis and Manufacturing Insights

The synthesis of 2-Methyl-3-nitro-benzeneacetic acid often involves multi-step organic reactions. A common route starts from precursors like 2-methyl-3-nitrobenzonitrile or related compounds. For example, a typical procedure might involve the reaction of a suitable nitrile with a strong base like potassium hydroxide in ethanol, followed by reflux and subsequent acidification. This process highlights the importance of precise reaction conditions to achieve high yields and purity. Manufacturers specializing in fine chemicals and pharmaceutical intermediates, particularly those based in China, are adept at producing this compound on both laboratory and industrial scales. For businesses looking to buy 2-methyl-3-nitro-benzeneacetic acid, engaging with a reputable manufacturer ensures that the product is produced under controlled conditions, meeting the stringent purity requirements essential for pharmaceutical applications.

Key Application: Ropinirole Hydrochloride Intermediate

The primary and most significant application of 2-Methyl-3-nitro-benzeneacetic acid is its role as a crucial intermediate in the synthesis of Ropinirole Hydrochloride. Ropinirole Hydrochloride is a dopamine agonist used in the treatment of Parkinson's disease and restless legs syndrome. The structural features of 2-Methyl-3-nitro-benzeneacetic acid make it an efficient starting material for building the complex molecular architecture of Ropinirole. Pharmaceutical companies worldwide rely on consistent access to this intermediate to maintain their production schedules and ensure the availability of these vital medications. Therefore, finding a reliable supplier that can provide this compound with consistent quality and a competitive price is a strategic objective for many pharmaceutical procurement departments.

Where to Procure High-Quality 2-Methyl-3-nitro-benzeneacetic Acid

When seeking to purchase 2-methyl-3-nitro-benzeneacetic acid, it is advisable to look for suppliers who emphasize quality control and provide detailed product specifications. Many leading chemical companies in China offer this intermediate, catering to international markets with competitive pricing and efficient delivery. Exploring online chemical marketplaces or directly contacting specialized chemical manufacturers can help identify trusted sources. The commitment to quality and regulatory compliance from your chosen supplier is paramount when this intermediate is intended for pharmaceutical use.

In summary, 2-Methyl-3-nitro-benzeneacetic acid is a cornerstone intermediate for specific pharmaceutical syntheses. Its chemical properties and synthetic accessibility, coupled with the manufacturing capabilities of global suppliers, ensure its continued importance in the production of essential medicines.