3,5-Bis(trifluoromethyl)acetophenone (CAS: 30071-93-3) is a fascinating molecule that holds significant importance in the realm of organic chemistry, particularly for its role as a versatile intermediate. As a fluorinated aromatic ketone, its unique structural features, specifically the two trifluoromethyl (-CF3) groups attached to the phenyl ring, impart a distinct set of chemical properties that drive its broad applicability.

Chemically, the presence of these highly electronegative trifluoromethyl groups renders the carbonyl carbon more electrophilic. This enhanced electrophilicity makes the compound highly reactive towards nucleophiles. The electron-withdrawing nature also influences the acidity of any alpha-hydrogens, though in this case, the acetyl group's hydrogens are still relatively acidic and can participate in reactions like halogenation or condensation under appropriate conditions.

The physical properties of 3,5-Bis(trifluoromethyl)acetophenone are also noteworthy. It typically presents as a clear, pale yellow liquid with a density of approximately 1.42 g/cm³. Its boiling point is around 95-98 °C at 15 mmHg, indicating moderate volatility. These characteristics are important for handling and reaction setup in laboratory and industrial settings.

The applications of this compound are wide-ranging and underscore its value to researchers and manufacturers. In pharmaceutical synthesis, it serves as a critical building block for creating complex molecular structures, including potential drug candidates for various therapeutic areas. Its incorporation can enhance metabolic stability and bioavailability, key factors in drug design. For those looking to buy this essential intermediate, a reliable supplier with a commitment to quality is paramount.

Beyond pharmaceuticals, 3,5-Bis(trifluoromethyl)acetophenone finds use in the agrochemical industry for the development of pesticides and herbicides, where its fluorinated nature can lead to increased efficacy and target specificity. It also plays a role in material science, contributing to the creation of advanced polymers and coatings with improved thermal and chemical resistance due to the stable C-F bonds.

When sourcing this chemical, consider a reputable manufacturer in China known for its stringent quality control and competitive pricing. Understanding the chemical properties of 3,5-Bis(trifluoromethyl)acetophenone allows chemists to fully leverage its potential in their synthesis, while procurement managers can ensure they are obtaining a high-quality, cost-effective product from a dependable supplier.