3-Chlorophenylboronic acid (CAS: 63503-60-6) is an organoboron compound that has garnered significant attention in the chemical industry due to its versatile chemical properties and broad application spectrum. Characterized by a boronic acid functional group attached to a phenyl ring bearing a chlorine atom at the meta position, this compound is a vital intermediate in numerous synthetic pathways, particularly in palladium-catalyzed cross-coupling reactions like the Suzuki-Miyaura coupling.

From a chemical perspective, 3-Chlorophenylboronic acid typically appears as a white to off-white crystalline powder. Its molecular formula is C6H6BClO2, with a molecular weight of approximately 156.37 g/mol. While it exhibits limited solubility in water, it readily dissolves in polar organic solvents such as tetrahydrofuran (THF), dimethylformamide (DMF), and methanol, facilitating its use in various reaction media. Its melting point generally falls within the range of 185-189 °C, indicative of its crystalline solid nature.

The core utility of 3-Chlorophenylboronic acid stems from its role as a nucleophilic coupling partner in Suzuki-Miyaura reactions. This process allows for the efficient formation of carbon-carbon bonds between aryl or vinyl halides and the boronic acid. The meta-chloro substituent on the phenyl ring offers a unique electronic signature that can influence reaction outcomes and the properties of the synthesized molecules. This makes it particularly valuable for constructing complex molecules used in pharmaceutical development and material science.

In pharmaceutical synthesis, 3-Chlorophenylboronic acid serves as a critical building block for creating active pharmaceutical ingredients (APIs) and intermediates. Its incorporation into drug candidates can influence their binding affinity to biological targets and their pharmacokinetic profiles. Researchers often buy this compound to explore new therapeutic agents, leveraging its versatility to synthesize diverse molecular structures. For consistent results, sourcing from a reliable manufacturer that guarantees high purity is essential.

In material science, this boronic acid derivative is employed in the synthesis of advanced functional materials. For instance, it can be used to create polymers with tailored electronic or optical properties, such as those used in organic electronics or specialized coatings. The ability to precisely control molecular architecture through cross-coupling reactions makes 3-Chlorophenylboronic acid a sought-after reagent for innovation in this field. We encourage chemists and procurement specialists to consider our high-quality 3-Chlorophenylboronic acid for their research and manufacturing needs, offering competitive pricing and reliable supply.