Understanding the precise chemical and physical properties of an intermediate is fundamental for any scientist or engineer aiming to utilize it effectively in synthesis. 4-Chlorophenyl Isocyanate, identified by CAS number 104-12-1, is a compound that warrants detailed examination due to its widespread use in the pharmaceutical and agrochemical sectors. As a dedicated supplier and manufacturer from China, we aim to provide clear insights into this crucial chemical.

Chemical and Physical Profile of 4-Chlorophenyl Isocyanate

4-Chlorophenyl Isocyanate possesses the molecular formula C7H4ClNO and a molecular weight of 153.57 g/mol. Its structure features a phenyl ring substituted with both a chlorine atom and an isocyanate group (-N=C=O). This isocyanate group is highly electrophilic and reactive, readily undergoing nucleophilic addition reactions. Its key physical characteristics include:

  • Appearance: Typically found as a white to yellow crystalline solid.
  • Melting Point: Ranges from 26-29 °C (lit.). This relatively low melting point means it can be a liquid or semi-solid at slightly elevated room temperatures.
  • Boiling Point: Approximately 203-204 °C (lit.).
  • Density: Around 1.2 g/mL at 25 °C.
  • Refractive Index: n20/D 1.5618 (lit.).
  • Solubility: It decomposes in water but is soluble in organic solvents such as toluene, dichloromethane, and ethyl acetate.
  • Sensitivity: It is sensitive to moisture and is lachrymatory (causes tearing), necessitating careful handling and storage in tightly sealed containers at refrigerated temperatures (2-8°C).

Industrial Applications Driven by Reactivity

The reactive nature of the isocyanate group makes 4-Chlorophenyl Isocyanate a valuable intermediate for various industrial syntheses:

  • Pharmaceutical Synthesis: It plays a vital role as a precursor in creating complex organic molecules with potential therapeutic applications. For example, it is used in the synthesis of certain derivatives that exhibit antibacterial, antifungal, and anti-tumor activities, making it a key compound for drug discovery researchers.
  • Agrochemical Manufacturing: In the agrochemical industry, it is used as a building block for pesticides and other crop protection agents. Its incorporation into molecules can impart specific biological activities beneficial for agricultural applications.
  • Polymer Chemistry: Isocyanates, in general, are monomers for polyurethanes and polyureas. While 4-Chlorophenyl Isocyanate might be used in more specialized polymer applications, its inherent reactivity points to this potential area.

For procurement managers and R&D scientists looking to buy 4-Chlorophenyl Isocyanate, understanding these properties is crucial for ensuring successful integration into their processes. As a supplier and manufacturer from China, we offer high-quality 4-Chlorophenyl Isocyanate with detailed technical data to support your needs. Contact us for a quote and to learn more about our supply capabilities.